Therapeutic Drug Monitoring of Beta-Lactams and Other Antibiotics in the Intensive Care Unit: Which Agents, Which Patients and Which Infections?

Drugs
Anouk E MullerAngela Huttner

Abstract

Antibiotics are among the medications most frequently administered to the critically ill, a population with high levels of intra- and inter-individual pharmacokinetic variability. Our knowledge of the relationships among antibiotic dosing, exposure and clinical effect in this population has increased in recent decades. Therapeutic drug monitoring (TDM) of serum antibiotic concentrations is the most practical means of assessing adequate antibiotic exposure, though until recently, it has been underutilised for this end. Now TDM is becoming more widespread, particularly for the beta-lactam antibiotics, a class historically thought to have a wide therapeutic range. We review the basic requirements, indications, and targets for effective TDM of the glycopeptides, aminoglycosides, quinolones and beta-lactam antibiotics in the adult intensive-care setting, with a special focus on TDM of the beta-lactam antibiotics, the most widely used antibiotic class.

References

Oct 1, 1975·The Journal of Infectious Diseases·H GiamarellouG G Jackson
Sep 1, 1992·Antimicrobial Agents and Chemotherapy·M L BarclayS T Chambers
Apr 1, 1990·The Journal of Antimicrobial Chemotherapy·M J RybakP H Chandrasekar
Oct 1, 1988·The Journal of Infectious Diseases·B VogelmanW A Craig
May 1, 1993·Antimicrobial Agents and Chemotherapy·A ForrestJ J Schentag
Apr 15, 1996·Annals of Internal Medicine·R HatalaD J Cook
Mar 1, 1996·The Pediatric Infectious Disease Journal·W A Craig, D Andes
Aug 1, 1996·Diagnostic Microbiology and Infectious Disease·W A Craig
Feb 10, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W A Craig
Jul 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M K LacyR Quintiliani
Feb 27, 1999·Antimicrobial Agents and Chemotherapy·A D KashubaJ S Bertino
Oct 6, 2000·Clinical Pharmacokinetics·A P Wilson
Sep 3, 2003·The Journal of Antimicrobial Chemotherapy·Sheryl A ZelenitskyRobert E Ariano
Jan 9, 2004·Infectious Disease Clinics of North America·Paul G AmbroseRobert C Owens
Mar 20, 2004·Nature Reviews. Microbiology·George L Drusano
Jun 25, 2004·Antimicrobial Agents and Chemotherapy·Joseph L KutiDavid P Nicolau
Oct 20, 2005·The Journal of Antimicrobial Chemotherapy·Sutep JaruratanasirikulSomchai Sriwiriyajan
Dec 14, 2005·The Journal of Antimicrobial Chemotherapy·Mical PaulLeonard Leibovici
Jul 4, 2006·American Journal of Infection Control·Michael J Rybak
Dec 5, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul G AmbroseGeorge L Drusano
Apr 24, 2007·The Lancet Infectious Diseases·Dafna YahavLeonard Leibovici
May 25, 2007·Fundamental & Clinical Pharmacology·Sarah N HilmerDavid G Le Couteur
Jun 20, 2007·Antimicrobial Agents and Chemotherapy·Johan W MoutonAlexander A Vinks
Jul 28, 2007·Pharmacotherapy·Manjunath P Pai, David T Bearden
Aug 30, 2008·Journal of Critical Care·Arthur R H van ZantenArmand R J Girbes
Nov 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Helen W BoucherJohn Bartlett
Dec 6, 2008·Therapeutic Drug Monitoring·Rhonda S ReaHoward Lee
Feb 11, 2009·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·Kazuhiro MatsuoMitsutoshi Satoh
Feb 25, 2009·Critical Care Medicine·Jason A Roberts, Jeffrey Lipman

❮ Previous
Next ❯

Citations

Jan 5, 2020·Analytical and Bioanalytical Chemistry·Sophia Rehm, Katharina M Rentsch
Apr 3, 2020·Expert Opinion on Drug Metabolism & Toxicology·Motoki FujiiYoshiro Hayashi
Apr 17, 2020·European Journal of Hospital Pharmacy. Science and Practice·Joan Antoni Schoenenberger-ArnaizMercedes Palomar-Martinez
Dec 13, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Claude MabilatIsabelle Caniaux
Sep 3, 2020·PloS One·Christopher R RosenbergKyle R Allison
Nov 14, 2018·Frontiers in Pediatrics·Tamara van DongeMarc Pfister
Mar 27, 2019·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Maria AnderssonHåkan Hanberger
Sep 6, 2019·British Journal of Clinical Pharmacology·Christer RimmlerGeorg Hempel
Mar 21, 2020·Frontiers in Pharmacology·Thierry BuclinLaurent A Decosterd
Jun 17, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jaclyn A CusumanoKerry L LaPlante
Aug 3, 2020·International Journal of Antimicrobial Agents·A MarsotR Guilhaumou
Sep 18, 2020·International Journal of Antimicrobial Agents·Suzanne L ParkerJason A Roberts
Feb 4, 2021·Journal of Clinical Pharmacy and Therapeutics·Nadine A SteffensNatália Brucker
Feb 10, 2021·Pathogens·Beata Kowalska-Krochmal, Ruth Dudek-Wicher
Feb 5, 2021·Clinical Pharmacology and Therapeutics·Kevin J Downes, Jennifer L Goldman
Nov 8, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Sophia Rehm, Katharina M Rentsch
Apr 21, 2021·Clinical Pharmacokinetics·Ibrahim El-HaffafAmélie Marsot
Jun 9, 2021·Annals of the Academy of Medicine, Singapore·Grace Si Ru HooLi Min Ling
Jun 18, 2021·International Journal of Clinical Pharmacy·Astrid Van WilderIsabel Spriet
Jul 19, 2021·Critical Care : the Official Journal of the Critical Care Forum·Renata Černá PařízkováVladimír Černý
Jul 11, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Eveline WallenburgRob Ter Heine
Aug 31, 2021·Open Forum Infectious Diseases·Nathan A PinnerJamie L Wagner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Related Papers

Thérapie
Nicolas VenisseGroupe Suivi Therapeutique Pharmacologique de la Societe Francaise de Pharmacologie et de Therapeutique
The Lancet Infectious Diseases
Olivier LortholaryClub de Reflexion sur les Infections en Onco-Hématologie
New Horizons : an Official Publication of the Society of Critical Care Medicine
C I Miyagawa
© 2022 Meta ULC. All rights reserved