Therapeutic drug monitoring of imatinib: Bayesian and alternative methods to predict trough levels.

Clinical Pharmacokinetics
V GottaThierry Buclin

Abstract

The imatinib trough plasma concentration (C(min)) correlates with clinical response in cancer patients. Therapeutic drug monitoring (TDM) of plasma C(min) is therefore suggested. In practice, however, blood sampling for TDM is often not performed at trough. The corresponding measurement is thus only remotely informative about C(min) exposure. The objectives of this study were to improve the interpretation of randomly measured concentrations by using a Bayesian approach for the prediction of C(min), incorporating correlation between pharmacokinetic parameters, and to compare the predictive performance of this method with alternative approaches, by comparing predictions with actual measured trough levels, and with predictions obtained by a reference method, respectively. A Bayesian maximum a posteriori (MAP) estimation method accounting for correlation (MAP-ρ) between pharmacokinetic parameters was developed on the basis of a population pharmacokinetic model, which was validated on external data. Thirty-one paired random and trough levels, observed in gastrointestinal stromal tumour patients, were then used for the evaluation of the Bayesian MAP-ρ method: individual C(min) predictions, derived from single random observations, wer...Continue Reading

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Oct 2, 2013·Wiener medizinische Wochenschrift·Thomas LionGünther Gastl
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Oct 28, 2021·British Journal of Clinical Pharmacology·Álvaro Corral AlaejosJonás Samuel Pérez-Blanco
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