Therapeutic Drug Monitoring of Long-Acting Injectable Antipsychotic Drugs.

Therapeutic Drug Monitoring
Georgios SchoretsanitisChristoph Hiemke

Abstract

The use of therapeutic drug monitoring (TDM) to guide treatment with long-acting injectable (LAI) antipsychotics, which are increasingly prescribed, remains a matter of debate. The aim of this review was to provide a practical framework for the integration of TDM when switching from an oral formulation to the LAI counterpart, and in maintenance treatment. The authors critically reviewed 3 types of data: (1) positron emission tomography data evaluating dopamine (D2/D3) receptor occupancy related to antipsychotic concentrations in serum or plasma; D2/D3 receptors are embraced as target sites in the brain for antipsychotic efficacy and tolerability, (2) pharmacokinetic studies evaluating the switch from oral to LAI antipsychotics, and (3) pharmacokinetic data for LAI formulations. Based on these data, indications for TDM and therapeutic reference ranges were considered for LAI antipsychotics. Antipsychotic concentrations in blood exhibited interindividual variability not only under oral but also under LAI formulations because these concentrations are affected by demographic characteristics such as age and sex, genetic peculiarities, and clinical variables, including comedications and comorbidities. Reported data combined with posi...Continue Reading

References

Jan 1, 1979·British Journal of Clinical Pharmacology·L B HansenE F Hvidberg
Oct 1, 1976·British Journal of Clinical Pharmacology·C Eggert HansenE F Hvidberg
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·T Aaes-Jørgensen
Nov 1, 1989·Pharmacopsychiatry·L P BalantG Garrone
May 1, 1986·The British Journal of Psychiatry : the Journal of Mental Science·H De CuyperD Verstraeten
Mar 1, 1985·Biological Psychiatry·L EreshefskyN R Burch
Apr 1, 1985·The British Journal of Psychiatry : the Journal of Mental Science·J TurbottL Hunter
Jan 1, 1983·Psychopharmacology·J K Saikia, A Jørgensen
Jun 1, 1983·The British Journal of Psychiatry : the Journal of Mental Science·A F FairbairnD Eccleston
Jan 1, 1982·International Pharmacopsychiatry·A J ReyntigensT J Aerts
Apr 1, 1995·Journal of Clinical Pharmacy and Therapeutics·R S MillerP Gillies
Feb 1, 1995·The American Journal of Psychiatry·S NybergL Bertilsson
Nov 1, 1995·International Clinical Psychopharmacology·S NybergC Halldin
Jan 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·M W JannW H Chang
Nov 1, 1996·The British Journal of Psychiatry : the Journal of Mental Science·E Tuninger, S Levander
Jan 1, 1997·The Journal of International Medical Research·E K SyvälahtiR K Salokangas

❮ Previous
Next ❯

Citations

Apr 7, 2021·European Archives of Psychiatry and Clinical Neuroscience·Georgios SchoretsanitisMichael Paulzen
Jun 19, 2021·Clinical Pharmacokinetics·Georgios SchoretsanitisMichael Paulzen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here