Therapeutic effect of human amniotic epithelial cells in murine models of Hashimoto's thyroiditis and Systemic lupus erythematosus

Cytotherapy
Bing TanLuyang Yu

Abstract

The chronic inflammation of autoimmune diseases develops repetitive localized destruction or systemic disorders, represented by Hashimoto's thyroiditis (HT) and Systemic lupus erythematosus (SLE) respectively. Currently, there are no efficient ways to treat these autoimmune diseases. Therefore, it is critically important to explore new therapeutic strategies. The aim of this study was to investigate the therapeutic efficacy of human amniotic epithelial cells (hAECs) in murine models of HT and SLE. Experimental autoimmune thyroiditis (EAT) was induced in female CBA/J mice by immunization with porcine thyroglobulin (pTg). hAECs were intravenously administered at different time points during the disease course. MRL-Faslpr mice, a strain with spontaneously occurring SLE, were intravenously administered hAECs when their sera were positive for both anti-nuclear antibodies (ANAs) and anti-double-stranded DNA (anti-dsDNA) antibodies. Two weeks after the last cell transplantation, blood and tissue samples were collected for histological examination and immune system analysis. hAECs prevented lymphocytes infiltration into the thyroid and improved the damage of thyroid follicular in EAT mice. Correspondingly, hAECs administration reduced ...Continue Reading

Citations

Jan 23, 2021·International Journal of Molecular Sciences·Quan-Wen LiuHong-Bo Xin
Oct 17, 2020·Stem Cell Research & Therapy·Qiuwan Zhang, Dongmei Lai
Oct 23, 2020·International Journal of Molecular Sciences·Chen QiuJinying Li
Apr 4, 2021·International Journal of Molecular Sciences·Marta MagattiOrnella Parolini
Aug 17, 2021·Frontiers in Immunology·Dragana Odobasic, Stephen R Holdsworth
Aug 24, 2021·International Journal of Endocrinology·Yang LiMan Tian
Oct 16, 2021·Frontiers in Cell and Developmental Biology·Jinying LiLuyang Yu

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