Therapeutic Effect of Ligustilide-Stimulated Adipose-Derived Stem Cells in a Mouse Thromboembolic Stroke Model

Cell Transplantation
Kang ChiShih-Ping Liu

Abstract

Stroke is a result of cerebral ischemia that triggers a cascade of both physiological and biochemical events. No effective treatment is available for stroke; however, stem cells have the potential to rescue tissue from the effects of stroke. Adipose-derived stem cells (ADSCs) are an abundant source of adult stem cells; therefore, ADSC therapy can be considered as a future strategy for regenerative medicine. However, more research is required to improve the effectiveness of transplanted ADSCs as a treatment for stroke in the mouse stroke model. Ligustilide, isolated from the herb Angelica sinensis, exhibits a protective effect on neurons and inhibits inflammation. We also demonstrated that ligustilide treatment increases the expression levels of homing factors such as SDF-1 and CXCR4. In the present study, we evaluated the therapeutic effects of ADSC transplantation and ligustilide treatment in a mouse thromboembolic stroke model by behavioral tests, including beam walking, locomotor activity, and rotarod analysis. ADSCs pretreated with ligustilide were transplanted into the brains of stroke mice. The results showed that the therapeutic effect of ADSCs pretreated with ligustilide was better than that of ADSCs without ligustilide...Continue Reading

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Citations

Dec 23, 2017·International Journal of Molecular Sciences·Cen-Hung LinShu-Hung Huang
Mar 7, 2020·Phytotherapy Research : PTR·Qingxuan XieXiaofang Li
May 19, 2021·European Journal of Pharmacology·Zhenhui LuoQun Lu

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Methods Mentioned

BETA
Assay
light microscopy
electrophoresis
flow cytometry

Software Mentioned

SigmaPlot

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