PMID: 16640862Apr 28, 2006Paper

Therapeutic effect of puerarin on rats with pre-eclampsia

Zhonghua fu chan ke za zhi
Chao WangQing Xiong

Abstract

To study the effect of puerarin on the nitrogen monoxide (NO) concentration in rats with pre-eclampsia. Thirty SD rats were selected and divided into three groups: normal pregnancy group, pre-eclampsia model group and puerarin group (10 rats in each group). We used endotoxin to set up the pre-eclampsia model rats on gestation 14th day and puerarin to treat these rats. The 24 hour urine protein on gestation 8th, 15th, 19th days were determined, as well as the heart rate, blood pressure on gestation 10th, 15th, 19th days. Nitrate reductase method was used to determine the plasma NO concentration of each group on gestation 21st day. (1) There was significant difference in urine protein concentration between the puerarin [(73 +/- 20) microg], pre-eclampsia [(464 +/- 57) microg], and normal pregnancy [(140 +/- 12) microg], groups (which is equal to the value of urine protein of pregnancy 19th day subtracting that of pregnancy 8th day, P < 0.01). (2) There was significant difference in blood pressure (which is equal to the value of blood pressure of pregnancy 19th day subtracting that of pregnancy 10th day) between the three groups (P < 0.01). (3) There was no significant difference in changes of heart rate between the three groups (...Continue Reading

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