Therapeutic effect of sentinel lymphadenectomy in T1 breast cancer

Archives of Surgery
D W OllilaA E Giuliano

Abstract

To evaluate whether the tumor status of the sentinel lymph node (SN) would alter the systemic adjuvant therapy administered to patients with T1 breast cancer. Consecutive breast cancer patients (tumors < or = 2 cm) who underwent successful sentinel lymphadenectomy. Metastatic tumor in the SN, primary tumor size, recommendations for systemic adjuvant therapy before and after histopathologic evaluation of the SN, and actual systemic adjuvant therapy received by the patient. Of 142 total patients, 14 had T1a tumors; 35, T1b; and 93, T1c. Recommendations for systemic adjuvant therapy were initially determined solely by primary tumor characteristics and menopausal status. These recommendations were compared with recommendations for systemic adjuvant therapy based on tumor characteristics, menopausal status, and SN status; and then were compared with actual systemic adjuvant therapy received by the patient. Among the 118 patients with T1a, T1b, and favorable (positive estrogen or progesterone receptors and a low S-phase percentage with respect to DNA content) T1c tumors, 15 (37.5%) of 40 premenopausal patients and 20 (25.6%) of 78 postmenopausal patients became candidates for chemotherapy when examination of the SN revealed axillary ...Continue Reading

Citations

Nov 7, 2000·Journal of Clinical Pathology·G Cserni
Jul 20, 2000·The Australian and New Zealand Journal of Surgery·A J Spillane, N P Sacks
Feb 28, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Cynthia CohenTravis Larsen
Mar 17, 1999·The American Journal of Surgical Pathology·R R TurnerA E Giuliano
Jul 14, 2000·Annals of Surgical Oncology·L A DiFronzoA E Giuliano
Jul 13, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A E GiulianoR R Turner
Nov 4, 2000·The Surgical Clinics of North America·B S SchwartzbergW E Kelley
Feb 28, 2001·Journal of the American College of Surgeons·S E Singletary

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