PMID: 6988911Jan 1, 1980Paper

Therapeutic effect of tamoxifen related to estrogen receptor level

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer
C RoseH T Mouridsen

Abstract

Cytoplasmic oestrogen receptor (ER) determinations were performed in 59 postmenopausal patients with metastatic breast cancer. Fifty percent of the patients were found to be ER+. Forty patients were treated with tamoxifen (TAM) and 19 patients were treated with tamoxifen plus medroxyprogesterone acetate (MPA). The response rate of TAM-treated patients was 30% (12/40). Of the 21 ER+ patients, ten (48%) responded to therapy. The ER values of these patients were significantly higher than the ER values of nonresponders (P less than 0.01). No correlation could be found between the ER value and the duration of remission in TAM-treated patients.

Citations

Sep 1, 1988·Breast Cancer Research and Treatment·S RotsteinL V von Stedingk
Jan 1, 1986·Breast Cancer Research and Treatment·C Kamby, C Rose

Related Concepts

Mammary Neoplasms, Human
Clinical Trials
Distilbène
Drug Evaluation
Polychemotherapy
Adgyn Medro
Menopause
Neoplasm Metastasis
Estrogen Nuclear Receptor
Remission, Spontaneous

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