Therapeutic effect of the natural compounds baicalein and baicalin on autoimmune diseases

Molecular Medicine Reports
Jian XuZhenzhong Gao

Abstract

A series of natural compounds have been implicated to be useful in regulating the pathogenesis of various autoimmune diseases. The present study demonstrated that the Scutellariae radix compounds baicalein and baicalin may serve as drugs for the treatment of autoimmune diseases, including rheumatoid arthritis and inflammatory bowel disease. Following the administration of baicalein and baicalin in vivo, T cell‑mediated autoimmune diseases in the mouse model were profoundly ameliorated: In the collagen‑induced arthritis model (CIA), the severity of the disease was reduced by baicalein and, consistently, baicalein was demonstrated to suppress T cell proliferation in CIA mice. In the dextran sodium sulfate (DSS)‑induced colitis model, the disease was attenuated by baicalin, and baicalin promoted colon epithelial cell (CEC) proliferation in vitro. The present study further revealed that the mRNA expression of signal transducer and activator of transcription (STAT)3 and STAT4 in the tyrosine‑protein kinase JAK‑STAT signaling pathway in T cells was downregulated by baicalein, contributing to its regulation of T cell proliferation. However, in the DSS model, the STAT4 transcription in CECs, which are the target cells of activated T ce...Continue Reading

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Citations

Aug 22, 2020·World Journal of Gastroenterology : WJG·Friederike CordesDominik Bettenworth
Jul 17, 2020·International Journal of Molecular Sciences·Thanasekaran JayakumarJoen-Rong Sheu
Dec 4, 2020·Biological & Pharmaceutical Bulletin·Gorrepotu Dani SusmithaYoshihiro Hayakawa
Mar 4, 2021·International Journal of Molecular Sciences·Valentina RizzoRiccardo Ientile
May 18, 2021·Frontiers in Pharmacology·Sha LiYibin Feng

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