Therapeutic effect of vitamin D in acute lower respiratory infection: A randomized controlled trial

Clinical Nutrition ESPEN
Sanjana H SomnathZachhariah Bobby

Abstract

To study the effect of vitamin D supplementation on the outcome of acute lower respiratory infection in hospitalized children. This is an open label parallel group randomized trial. Total of 154 children aged 2 mo-5 yrs (mean age 13 mo) admitted with acute lower respiratory infection (ALRI) were randomized to receive standard care therapy alone or standard care therapy for the respiratory infection along with a single oral dose of 100,000 IU of vitamin D3. Serum 25(OH)D levels were measured at admission in all the children and 72 h after administration of vitamin D in the supplemented group. Primary outcome measured was the duration of hospital stay. Secondary outcomes measured were mortality, incidence of complications, admission to PICU and recurrence of respiratory infections within 90 days of discharge. Primary outcome was compared using Mann Whitney U test and secondary outcomes were compared using chi-square or Fischer's exact test. Baseline characteristics were comparable between the two groups. There was no statistically significant difference in the primary outcome (Median duration of hospital stay in both the groups) and also in secondary outcomes (mortality, PICU admission, complications and recurrence of respiratory...Continue Reading

Citations

Jul 20, 2018·The Cochrane Database of Systematic Reviews·Rashmi R DasSushree S Naik
Oct 11, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Chao YangGuiju Sun
Dec 12, 2020·The Cochrane Database of Systematic Reviews·Samantha L HueySaurabh Mehta
Oct 24, 2020·Nutrients·Francesco PecoraSusanna Esposito

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