Therapeutic effects and mechanisms of total flavonoids of Turpinia Arguta Seen on adjuvant arthritis in rats

Journal of Ethnopharmacology
Lei ZhangYong Li

Abstract

To investigate the therapeutic effects and mechanisms of total flavonoids of Turpinia Arguta Seen (TFS) on adjuvant arthritis in rats. The model of adjuvant arthritis was induced by injection of Freund's Complete Adjuvant (FCA). Secondary paw swelling of AA rats was measured with volume meter and polyarthritis index were scored. The splenocyte proliferation, (interleukin-1) IL-1 and interleukin-2 (IL-2) production were assayed by cell proliferation assay. Prostaglandin E(2) (PGE(2)) production was determined by radioimmunoassay. TFS (80, 160, 320 mg/kg, i.g.) could significantly inhibit secondary inflammatory reaction (secondary swelling, multiple arthritis, pathologic change of ankle arthritis) in AA rats. The results in vivo showed that the low response of splenocytes to concanavalin A (Con A) and lipopolysaccharide (LPS) and the decreased IL-2 synthesis were restored in AA rats treated with TFS (160, 320 mg/kg, i.g.), while the elevated IL-1 and PGE(2) released from peritoneal macrophages (PMphi) were also reduced. TFS has significant therapeutic effect on AA rats, which might be relate to its immunoregulatory actions.

References

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Citations

Jan 27, 2009·Acta Pharmacologica Sinica·Yan-Li LiuZheng-Hong Qin
Jan 15, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Shivaprasad H VenkateshaKamal D Moudgil
Jan 24, 2014·Immunopharmacology and Immunotoxicology·Huaxun WuWei Wei
Feb 25, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Cui-Ping JiangChun-Su Yuan
Jan 21, 2017·International Journal of Biological Macromolecules·Abdul-Rehman PhullSong Ja Kim
Jan 19, 2019·Chemistry & Biodiversity·Thalía I Ramírez-ReyesJosé A Guerrero-Analco
Dec 1, 2010·Bioorganic & Medicinal Chemistry·Shivaprasad H VenkateshaKamal D Moudgil

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