Abstract
The present study was conducted to investigate the effects of Baicalein (BE), which is hydrolyzed product of Baicalin (BA), on atopic dermatitis (AD). AD was induced in NC/Nga mice by DPE treatment. BE hydrogels treatment reduced the levels of skin severity scores. BE hydrogels treatment also decreased inflammatory cytokines such as TNF-alpha, IL-6, and its level in the serum. BE hydrogels treatment elevated IFN-gamma level in the spleenocyte culture supernatant. Cell numbers in the skin positive to CD3+/CD69+, CCR3+, CD11b+/Gr-1+, B220+/IgE+ all of which were up-regulated in AD-induced mice were decreased and returned to normal levels. Histological examination showed that infiltration levels of immune cells in the skin of AD-induced NC/Nga mice were much improved by BE hydrogels treatment. These results thus suggest that BE can regulate molecular mediators and immune cells that are functionally associated with atopic dermatitis induced in NC/Nga mice, and may play an important role in recovering AD symptoms.
References
Apr 1, 1992·Allergy·C F Wahlgren
Dec 1, 1995·Clinical Immunology and Immunopathology·M R LesterD Y Leung
Jul 27, 1999·The Journal of Investigative Dermatology·N YawalkarM Baggiolini
Aug 19, 1999·Critical Reviews in Oncology/hematology·P Bradding, S T Holgate
Oct 19, 1999·The Journal of Clinical Investigation·C VestergaardK Matsushima
Oct 26, 1999·International Archives of Allergy and Immunology·H SutoC Ra
Jan 15, 2000·The Journal of Dermatology·C F Wahlgren
Apr 27, 2000·Molecular Medicine Today·C VestergaardK Matsushima
Sep 21, 2000·Immunopharmacology·B Q LiJ M Wang
Jun 16, 2001·International Immunopharmacology·S SakumaT Goto
Oct 16, 2001·Immunology Letters·N SudoC Kubo
Dec 26, 2001·International Archives of Allergy and Immunology·T SasakawaH Matsuda
Mar 21, 2002·The British Journal of Dermatology·M MatsumotoT Tanaka
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Jonathan M Spergel, Amy S Paller
Jul 22, 2004·Journal of Dermatological Science·Yuki HashimotoShiro Nakaike
Sep 2, 2004·Biological & Pharmaceutical Bulletin·Xiu Kun GaoHiroichi Nagai
Aug 22, 2006·International Immunopharmacology·Jong Soon KangHwan Mook Kim
Nov 28, 2007·Clinical and Molecular Allergy : CMA·Chia-Jung HsiehDavid S Chi
Citations
Dec 21, 2012·Chinese Medicine·Hyo Won JungYong-Ki Park
Jul 31, 2013·PloS One·Yan ZhangZhenlin Hu
Sep 13, 2013·Drug Development and Industrial Pharmacy·Shiow-Fern NgYong-Boey Sin
Jan 18, 2011·International Immunopharmacology·Hua ZhengGeun Eog Ji
Apr 24, 2013·Journal of Applied Microbiology·J-Y KimS Pyo
Jan 10, 2012·The Journal of Pharmacy and Pharmacology·Na-Ra HanHyun-Ja Jeong
Mar 19, 2014·Journal of Ethnopharmacology·Hee Soon ShinDong-Hwa Shon
Jan 24, 2012·Journal of Ethnopharmacology·Si QinDe-Xing Hou
Apr 26, 2011·Experimental Neurology·Roman StavniichukIrina G Obrosova
May 30, 2015·BMC Complementary and Alternative Medicine·Yi LiuXiaojin Liu
Apr 4, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Seong Eun JinSoo-Jin Jeong
Jun 13, 2012·Journal of Ethnopharmacology·Hyo Won JungYong-Ki Park
Aug 27, 2016·Scientific Reports·Min-Jung BaeDong-Hwa Shon
Jun 21, 2019·Scientific Reports·Bernie Byunghoon ParkYoung Ho Jeon
Mar 31, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Güçlü Kaan BeriatBizden Sabuncuoğlu
Dec 5, 2018·Gastroenterology Research and Practice·Hui YangXu Liu
Jul 31, 2018·Dermatology Research and Practice·Kotaro ItoShinichi Imafuku
Jul 28, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ly Thi Huong NguyenHeung-Mook Shin
Mar 16, 2021·Journal of Ethnopharmacology·Lan WangJustin Che Yuen Wu
May 1, 2021·Animals : an Open Access Journal From MDPI·Baishuang YinXuezhao Sun
Jun 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shi WuJinhao Zeng
Jul 3, 2021·International Journal of Molecular Sciences·Hanon LeeJin Ho Chung