Therapeutic effects of Baicalein on atopic dermatitis-like skin lesions of NC/Nga mice induced by dermatophagoides pteronyssinus

International Immunopharmacology
Mi-Young YunSang-Chul Shin

Abstract

The present study was conducted to investigate the effects of Baicalein (BE), which is hydrolyzed product of Baicalin (BA), on atopic dermatitis (AD). AD was induced in NC/Nga mice by DPE treatment. BE hydrogels treatment reduced the levels of skin severity scores. BE hydrogels treatment also decreased inflammatory cytokines such as TNF-alpha, IL-6, and its level in the serum. BE hydrogels treatment elevated IFN-gamma level in the spleenocyte culture supernatant. Cell numbers in the skin positive to CD3+/CD69+, CCR3+, CD11b+/Gr-1+, B220+/IgE+ all of which were up-regulated in AD-induced mice were decreased and returned to normal levels. Histological examination showed that infiltration levels of immune cells in the skin of AD-induced NC/Nga mice were much improved by BE hydrogels treatment. These results thus suggest that BE can regulate molecular mediators and immune cells that are functionally associated with atopic dermatitis induced in NC/Nga mice, and may play an important role in recovering AD symptoms.

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Citations

Jan 10, 2012·The Journal of Pharmacy and Pharmacology·Na-Ra HanHyun-Ja Jeong
Mar 19, 2014·Journal of Ethnopharmacology·Hee Soon ShinDong-Hwa Shon
May 30, 2015·BMC Complementary and Alternative Medicine·Yi LiuXiaojin Liu
Apr 4, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Seong Eun JinSoo-Jin Jeong
Jun 21, 2019·Scientific Reports·Bernie Byunghoon ParkYoung Ho Jeon
Mar 31, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Güçlü Kaan BeriatBizden Sabuncuoğlu
Jul 31, 2018·Dermatology Research and Practice·Kotaro ItoShinichi Imafuku
Jul 28, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ly Thi Huong NguyenHeung-Mook Shin
Mar 16, 2021·Journal of Ethnopharmacology·Lan WangJustin Che Yuen Wu
May 1, 2021·Animals : an Open Access Journal From MDPI·Baishuang YinXuezhao Sun
Jun 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shi WuJinhao Zeng
Jul 3, 2021·International Journal of Molecular Sciences·Hanon LeeJin Ho Chung

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