Abstract
Experimental autoimmune encephalomyelitis (EAE) is a prototypic Th1-mediated autoimmune inflammatory disease of the central nervous system (CNS), and serves as a model for the human demyelinating disease, multiple sclerosis. Cisplatin is a drug widely used in the treatment of a variety of human neoplasias, such as advanced bladder carcinoma, adrenal cortex carcinoma, breast cancer, head and neck or lung carcinoma. Cisplatin binds to DNA and interferes with cellular repair and other mechanism, which eventually result into cell death. It is known that cisplatin can induce immunosuppressive effects through inhibition of T cell activity. Therefore we analyzed the anti-inflammatory effects of cisplatin in a rat EAE model. EAE was induced in male LEW rats by immunizing with a synthetic peptide of guinea pig myelin basic protein. The development of EAE and neurological signs were evaluated by a standard protocol. Immunohistochemistry was applied to show immune cell infiltration into the CNS. Early treatment of EAE rats with cisplatin effectively ameliorated the development of disease and provided a significant protective effect compared to control rats. Further, histological analysis demonstrated that the formation of the typical peri...Continue Reading
Citations
May 3, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hui-min ZhengBao-yu Guo
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Cory TeuscherElizabeth P Blankenhorn
Mar 2, 2006·Arthritis Research & Therapy·Maria LiljanderRagnar Mattsson
Apr 21, 2006·Genetics·Johan OckingerMaja Jagodic
Aug 19, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Laura GarayAlejandro F De Nicola
Aug 13, 2013·Journal of Proteomics·Gro L StørvoldBernd Thiede
Jan 23, 2015·Chemotherapy Research and Practice·Lidia ZuevaMikhail Inyushin
Jun 4, 2015·PloS One·Marta Tejera-AlhambraSilvia Sánchez-Ramón
Sep 16, 2016·Neural Regeneration Research·Tigran R PetrosyanAnna S Hovsepyan
Mar 11, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·K B MarquesA L R Oliveira
Feb 10, 2018·Journal of the American College of Nutrition·Quadri Kunle AlabiKehinde Peace Olamilosoye
May 28, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Abdelazeem Ali KhalafAnupam Bishayee
May 14, 2016·Oncotarget·Woo Sik KimSung Jae Shin
Feb 9, 2017·Journal of Neurochemistry·Noha F AbdelkaderRania M Abdelsalam
Nov 5, 2013·Physiological Research·B H AliA Nemmar