Therapeutic effects of cisplatin on rat experimental autoimmune encephalomyelitis

Archivum Immunologiae Et Therapiae Experimentalis
Xiao-Bo Li, Hermann J Schluesener

Abstract

Experimental autoimmune encephalomyelitis (EAE) is a prototypic Th1-mediated autoimmune inflammatory disease of the central nervous system (CNS), and serves as a model for the human demyelinating disease, multiple sclerosis. Cisplatin is a drug widely used in the treatment of a variety of human neoplasias, such as advanced bladder carcinoma, adrenal cortex carcinoma, breast cancer, head and neck or lung carcinoma. Cisplatin binds to DNA and interferes with cellular repair and other mechanism, which eventually result into cell death. It is known that cisplatin can induce immunosuppressive effects through inhibition of T cell activity. Therefore we analyzed the anti-inflammatory effects of cisplatin in a rat EAE model. EAE was induced in male LEW rats by immunizing with a synthetic peptide of guinea pig myelin basic protein. The development of EAE and neurological signs were evaluated by a standard protocol. Immunohistochemistry was applied to show immune cell infiltration into the CNS. Early treatment of EAE rats with cisplatin effectively ameliorated the development of disease and provided a significant protective effect compared to control rats. Further, histological analysis demonstrated that the formation of the typical peri...Continue Reading

Citations

May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Cory TeuscherElizabeth P Blankenhorn
Mar 2, 2006·Arthritis Research & Therapy·Maria LiljanderRagnar Mattsson
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