PMID: 11345389May 10, 2001Paper

Therapeutic effects of FTY720, a new immunosuppressive agent, in a murine model of acute viral myocarditis

Journal of the American College of Cardiology
Tadashi MiyamotoS Sasayama

Abstract

This study examines the efficacy of FTY720 (FTY), a new immunosuppressor, in the treatment of acute viral myocarditis in a murine model. Immunosuppressive agents have no proven therapeutic efficacy in experimental or clinical myocarditis. Encephalomyocarditis virus was inoculated i.p. in DBA/2 mice on day 0. Postinoculation treatment consisted of FTY 10 mg/kg/day p.o. (FTY group), or cyclosporine A (CsA) 40 mg/kg/day p.o. (CsA group) or distilled water p.o. only (control group). Survival until day 14, as well as cardiac histopathology, virus concentrations, cytokines (interleukin [IL]-2, IL-12, interferon [IFN]-gamma and tumor necrosis factor [TNF]-alpha) and nitric oxide (NO) on day 5 were examined. In the control and CsA groups, all mice died within 10 and 7 days, respectively. However, in the FTY group, 27% of the animals survived up to day 14. Compared with the control group, 1) histological scores were significantly lower in the FTY group but unchanged in the CsA group; 2) virus concentration was significantly higher in the CsA group but not in the FTY group; 3) expressions of IL-2, IL-12 and IFN-gamma in the heart were suppressed in both the FTY and CsA groups, though suppression was weaker in the FTY group; 4) TNF-alpha ...Continue Reading

References

Mar 1, 1992·Clinical Immunology and Immunopathology·H HanawaA Shibata
Aug 1, 1991·European Heart Journal·M HerzumB Maisch
Apr 1, 1986·Journal of the American College of Cardiology·N TomiokaC Kawai
Feb 1, 1986·Circulation·J B O'ConnellJ A Robinson
Jul 1, 1994·Journal of Molecular and Cellular Cardiology·M HerzumB Maisch
May 1, 1996·Current Opinion in Cardiology·B MaischU Schonian
Oct 31, 1996·Nature·A K AbbasA Sher
Dec 1, 1996·Journal of Molecular and Cellular Cardiology·A MatsumoriS Sasayama
Sep 23, 1997·Journal of Molecular and Cellular Cardiology·T ShioiS Sasayama
Mar 20, 1999·Transplantation Proceedings·S KunikataT Kurita
Jul 31, 1999·Immunopharmacology·Z J LuoM Miyasaka
Sep 8, 1999·Circulation·R NishioS Sasayama
Mar 10, 2000·Journal of Cardiovascular Pharmacology·H KitabayashiM Sekiguchi

❮ Previous
Next ❯

Citations

Mar 26, 2004·Transplantation Proceedings·B D Kahan
Aug 17, 2002·Current Opinion in Immunology·Volker Brinkmann, Kevin R Lynch
Feb 9, 2005·Transplantation·Klára SedlákováJohn V Forrester
Sep 1, 2005·Future Cardiology·Akira Matsumori
Jul 7, 2009·Pharmacology & Therapeutics·Andrea Huwiler, Josef Pfeilschifter
Jun 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Volker BrinkmannTimothy Hla
Jul 2, 2003·Expert Opinion on Biological Therapy·Fazil Tuncay Aki, Barry D Kahan
Jun 12, 2016·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Ferenc BoldizsarTibor A Rauch
Aug 19, 2005·Expert Review of Anti-infective Therapy·Zhen LiuDecheng Yang
May 4, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Francesco PotìJerzy-Roch Nofer
Apr 1, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·R FujiiM Watanabe
Jun 27, 2003·Current Opinion in Cardiology·Jesus Vallejo, Douglas L Mann
Aug 6, 2020·Frontiers in Cellular and Infection Microbiology·Cong ZhangZhen Yang
Apr 23, 2002·The Journal of Biological Chemistry·Volker BrinkmannKevin R Lynch

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.