Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation

Journal of Clinical Medicine
Youngpyo NamSang Ryong Kim

Abstract

Cerebellar ataxias (CAs) are neurological diseases characterized by loss of muscle coordination that is a result of damage and inflammation to the cerebellum. Despite considerable efforts in basic and clinical research, most CAs are currently incurable. In this study, we evaluated the therapeutic potential of human mesenchymal stem cells (hMSCs) against CAs associated with neuroinflammation. We observed that hMSC treatment significantly inhibited the symptoms of ataxia in lipopolysaccharide (LPS)-induced inflammatory CA (ICA) mice, which were recently reported as a potential animal model of ICA, through the anti-inflammatory effect of hMSC-derived TNFα-stimulated gene-6 (TSG-6), the protection of Purkinje cells by inhibition of apoptosis, and the modulatory effect for microglial M2 polarization. Thus, our results suggest that hMSC treatment may be an effective therapeutic approach for preventing or improving ataxia symptoms.

References

Sep 14, 2001·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S GabsiF Hentati
Aug 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·M HadjivassiliouR A Grünewald
Oct 24, 2006·Nature Clinical Practice. Neurology·Brent L Fogel, Susan Perlman
May 14, 2008·Current Neurovascular Research·Lixian JiangAlison E Willing
Jan 20, 2010·Lancet Neurology·Thomas Klockgether
Sep 3, 2010·Current Neuropharmacology·D Marmolino, M Manto
Nov 19, 2010·Regenerative Medicine·Nanette JoyceJan A Nolta
Aug 11, 2011·Handbook of Clinical Neurology·Mario Manto
Jul 6, 2012·Journal of Child Neurology·Brent L Fogel
Jul 12, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lian LiQuan Jiang
Aug 13, 2013·The Journal of Clinical Investigation·Laura CutandoAndrés Ozaita
Feb 15, 2014·Free Radical Biology & Medicine·Michele Longoni CalióClélia Rejane Antônio Bertoncini
Jun 4, 2014·Journal of Neuroinflammation·Jonathan D CherryM Kerry O'Banion
Nov 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ryang Hwa LeeDarwin J Prockop
Jan 20, 2015·Molecular Neurobiology·Yu Tang, Weidong Le
Mar 12, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Adolfo Ramirez-ZamoraJosé Biller
Aug 19, 2015·Journal of Natural Science, Biology, and Medicine·Shubhankar MishraAshok Kumar Nanda
Dec 25, 2015·Swiss Medical Weekly·Adelaida SarukhanAntonella Viola
Jul 18, 2016·Neuroimaging Clinics of North America·Andrea RossiDomenico Tortora
Sep 1, 2016·Experimental Cell Research·Gyöngyi KudlikFerenc Uher
Oct 13, 2016·Cerebellum & Ataxias·Priya D ShanmugarajahMarios Hadjivassiliou
Oct 27, 2016·Brain and Behavior·Yogi Chang-Yo HsuanMao-Tsun Lin
May 4, 2017·Current Research in Translational Medicine·A GugliandoloE Mazzon

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
density gradient centrifugation
confocal microscopy
electrophoresis

Software Mentioned

Multi Gauge
SigmaPlot

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

© 2021 Meta ULC. All rights reserved