Therapeutic effects of liposome-enveloped Ligusticum chuanxiong essential oil on hypertrophic scars in the rabbit ear model.

PloS One
Hong ZhangCheng Peng

Abstract

Hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, results from an overproduction of fibroblasts and excessive deposition of collagen. Although treatment with surgical excision or steroid hormones can modify the symptoms, numerous treatment-related complications have been described. In view of this, we investigated the therapeutic effects of essential oil (EO) from rhizomes of Ligusticum chuanxiong Hort. (Umbelliferae) on formed hypertrophic scars in a rabbit ear model. EO was prepared as a liposomal formulation (liposome-enveloped essential oil, LEO) and a rabbit ear model with hypertrophic scars was established. LEO (2.5, 5, and 10%) was applied once daily to the scars for 28 days. On postoperative day 56, the scar tissue was excised for masson's trichrome staining, detection of fibroblast apoptosis, assays of the levels of collagens I and III, and analysis of the mRNA expression of matrix metalloproteinase-1 (MMP-1), caspase-3 and -9, and transforming growth factor beta 1 (TGF-β(1)). In addition, the scar elevation index (SEI) was also determined. As a result, LEO treatment significantly alleviated formed hypertrophic scars on rabbit ears. The levels of TGF-β(1), MMP-1, collagen I, and collagen III...Continue Reading

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Citations

May 21, 2013·Advances in Skin & Wound Care·Zhibo Xiao, Chen Xi
Jul 25, 2013·Journal of Liposome Research·Mirna SherryHélène Greige-Gerges
Apr 1, 2016·Journal of Food and Drug Analysis·Hsin-Yi Hung, Tian-Shung Wu
Jul 27, 2021·International Journal of Dermatology·Kesrin AmraFateh Khan

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Methods Mentioned

BETA
biopsy
ELISA
reverse transcription-PCR

Software Mentioned

Primer Express

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