PMID: 11917240Mar 28, 2002Paper

Therapeutic effects of nonnucleoside reverse transcriptase inhibitors on the central nervous system in HIV-1-infected patients

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Hans Jürgen von GiesenGabriele Arendt

Abstract

Psychomotor slowing predicts the development of HIV-1-associated dementia, AIDS, and death independent of immune status. We retrospectively selected all patients who showed pathologic psychomotor slowing as a sign of central nervous system (CNS) dysfunction before the onset of therapy and who were then treated with nonnucleoside reverse-transcriptase inhibitors-either efavirenz (EFV) (n = 65 patients) or nevirapine (NVP) (n = 39 patients), each given in combination with two nucleoside analogues (NAs). Patients who were treated only with two NAs (n = 66) served as controls. Patients were observed for 6 months. Both EFV and NVP combinations improved CNS function as determined by electrophysiologic motor tests. The therapeutic effects of EFV and NVP did not depend on the type of NA added. Although results did not reach significance, NVP combinations were more effective than EFV combinations or therapy regimens with NAs alone in patients who were naïve to all antiretroviral therapy. EFV and NVP combinations were equally effective in patients pretreated with highly active antiretroviral therapy, including protease inhibitors.

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Citations

Jan 21, 2014·Environmental Toxicology and Pharmacology·Hugo Martins de OliveiraVanessa M Andrade
Jan 5, 2006·Cerebrospinal Fluid Research·Christy AnthonypillaiSarah A Thomas
Jul 19, 2013·Pharmacogenomics·Almudena Sánchez MartínAngel Carracedo Álvarez
Jun 19, 2009·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Christopher PowerM John Gill
Oct 23, 2010·The International Journal of Neuroscience·G I T CavalcanteM M F Fonteles
Apr 21, 2011·Expert Review of Anti-infective Therapy·Pornpun VivithanapornChristopher Power
Mar 21, 2007·Expert Opinion on Drug Safety·Gabriele ArendtThorsten Nolting
Jun 26, 2012·Médecine et maladies infectieuses·P DellamonicaR Garraffo
Aug 2, 2006·HIV Clinical Trials·Bryan McGeeFrancesca Aweeka
Nov 25, 2003·HIV Clinical Trials·Hans Jürgen von GiesenGabriele Arendt
Sep 10, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mahamad Yunnus A MahatShilpee Chaudhary
Sep 10, 2016·African Journal of Primary Health Care & Family Medicine·Rachael N KinuthiaJoseph M Thigiti
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Feb 5, 2004·Current Treatment Options in Neurology·Avindra Nath, Joseph Berger
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Jan 15, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hans-Jürgen von GiesenGabriele Arendt
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