Therapeutic effects of probiotics on neurotoxicity induced by clindamycin and propionic acid in juvenile hamsters

Metabolic Brain Disease
Nora Al-OrfAbir Ben Bacha

Abstract

The present study investigated the therapeutic effects of probiotics on brain intoxication induced by clindamycin and propionic acid (PPA) in hamsters. Fifty golden Syrian hamsters were randomly divided into five experimental groups of ten animals each: (A) control group receiving phosphate buffered saline; (B) oral buffered PPA-treated group being administered with a neurotoxic dose of 250 mg/kg PPA during three days; (C) oral clindamycin-treated group receiving a single dose of 30 mg clindamycin/kg; and (D, E) the two therapeutic groups being administered the same doses of clindamycin and PPA followed by probiotics for three weeks at a daily dose of 0.2 g/kg. Biochemical parameters of energy metabolism and oxidative stress were examined in brain homogenates from all hamsters. The development of pathogenic bacteria was monitored on stool samples from all hamsters. Descriptive changes in fecal microbiota and overgrowth of Clostridium species in clindamycin and PPA treated hamsters were recorded. Interestingly, probiotics were shown effective to restore normal gut microbiota. Clindamycin and PPA treatments caused an elevation in lipid peroxidation and catalase activity, as oxidative stress markers, together with a reduction in G...Continue Reading

References

Aug 1, 1987·Metabolism: Clinical and Experimental·E P Brass, R A Beyerinck
Jan 1, 1984·The International Journal of Biochemistry·W R Chegwidden, D C Watts
Sep 26, 1994·The American Journal of Medicine·B Frei
Jan 1, 1993·Brain Research. Brain Research Reviews·J M BronsteinC G Wasterlain
Oct 30, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·T J MonksE A Lock
Aug 11, 2004·Journal of Inherited Metabolic Disease·M WajnerC S Dutra-Filho
Dec 9, 2004·The American Journal of Clinical Nutrition·S Jill JamesJames A Neubrander
Feb 16, 2006·Cleveland Clinic Journal of Medicine·Rebecca H Sunenshine, L Clifford McDonald
Jun 20, 2006·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Ved Chauhan, Abha Chauhan
Feb 22, 2007·The Journal of Nutrition·Marcel Roberfroid
Dec 1, 2004·Nutrition Research Reviews·Glenn R GibsonMarcel B Roberfroid
May 1, 2009·Nature Reviews. Gastroenterology & Hepatology·Sang H RheeEmeran A Mayer
Oct 5, 2010·Psychopharmacology·Siobhain M O'MahonyJohn F Cryan
May 20, 2011·Medical Hypotheses·Sydney M Finegold
Jul 14, 2011·Nature Reviews. Neuroscience·Emeran A Mayer
Apr 26, 2012·Journal of Neuroinflammation·Afaf K El-AnsaryMalak Kotb
Sep 13, 2012·Nature Reviews. Neuroscience·John F Cryan, Timothy G Dinan
Sep 25, 2012·Nature Reviews. Microbiology·Stephen M CollinsPremysl Bercik
Mar 26, 2014·The Journal of Physiology·Adam D FarmerQasim Aziz
Jul 6, 2014·Advances in Experimental Medicine and Biology·Yuliya E BorreJohn F Cryan
Apr 26, 2016·Journal of Human Reproductive Sciences·Sarika Amdekar, Vinod Singh
Jan 17, 2017·Nature Neuroscience·Thomas C FungElaine Y Hsiao

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Citations

Jan 28, 2021·Medicinal Research Reviews·Laiying ZhangYoufu Luo
Jan 29, 2021·Frontiers in Aging Neuroscience·Jessica KillingsworthR Douglas Shytle

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