Therapeutic effects of simvastatin on Galectin-3 and oxidative stress parameters in endotoxemic lung tissue

Bioscience Reports
Hatice YorulmazSule Tamer

Abstract

Galectins constitute of a soluble mammalian β-galactoside binding lectin family, which play homeostatic roles in the regulation of the cell cycle, and apoptosis, in addition to their inflammatory conditions. Galectin-3 has an important role in the regulation of various inflammatory conditions including endotoxemia, and airway inflammation. Statins, the key precursor inhibitors of 3-hydroxyl-3-methyl coenzyme A (HMG-CoA) reductase, may prevent the progression of inflammation in sepsis after prior statin treatment. Endotoxemia leads to the formation of oxidative stress parameters in proteins, carbohydrates, and DNA. In the present study, we aimed to show the effects of simvastatin on Galectin-3, and glutathione reductase (GR), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and thiobarbituric acid reactive substances (TBARS) levels in lung tissue of rats which were treated with lipopolysaccharides (LPS) during the early phase of sepsis. Rats were divided into four groups as the control, LPS (20 mg/kg), simvastatin (20 mg/kg), and simvastatin+LPS group. Galectin-3 expression in formalin-fixed paraffin-embedded lung tissue sections was demonstrated by using the immunohistochemistry methods. There were reduced densities...Continue Reading

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
Jan 1, 1988·Free Radical Biology & Medicine·J T Flaherty, M L Weisfeldt
Jan 1, 1981·Microbiology and Immunology·S SakaguchiO Sakaguchi
Feb 29, 2000·Metabolism: Clinical and Experimental·D J Betteridge
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H SanoF T Liu
Sep 21, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A P LiappisG L Simon
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sachiko SatoMichel G Bergeron
Oct 7, 2003·Vascular and Endovascular Surgery·Daphne Pierre-Paul, Vivian Gahtan
Jan 13, 2005·Drugs of Today·Lynn L StollNeal L Weintraub
Apr 9, 2005·Intensive Care Medicine·Hulya BabayigitHulya Akgun
Jul 7, 2005·Circulation·Marc W MerxChristian Weber
Nov 12, 2005·Intensive Care Medicine·Peter KrugerGraeme Nimmo
Aug 8, 2006·Biochemical and Biophysical Research Communications·Simon Wing Fai MokMichael Baier
Feb 13, 2007·Acta Cirúrgica Brasileira·José Luiz de Souza NetoAldo Cunha Medeiros
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yubin LiDamo Xu
Jan 30, 2009·Experimental Biology and Medicine·Mani ChopraAvadhesh C Sharma
Jul 15, 2009·Immunological Reviews·Neil C Henderson, Tariq Sethi
Oct 28, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Peng WangChun-xu Hai
Oct 28, 2011·PloS One·Marise Lopes FerminoLise Halbwachs-Mecarelli
Jan 20, 2012·Annals of the New York Academy of Sciences·Dianne CooperMauro Perretti
Aug 7, 2014·Journal of the American Heart Association·Julio Madrigal-MatuteJose Luis Martin-Ventura
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Dec 23, 2017·Biochemical and Biophysical Research Communications·C H HanW W Liu

❮ Previous
Next ❯

Citations

Sep 26, 2020·Frontiers in Immunology·Juan Garcia-RevillaAntonio Boza-Serrano
Jun 10, 2020·Canadian Journal of Physiology and Pharmacology·Yunpeng TianMinghao Song
Nov 4, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Philip A EfronLyle L Moldawer

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked
ELISA
enzyme-linked immunosorbent assay

Software Mentioned

Statistical package for the Social Sciences ( SPPS )

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here