Therapeutic effects of streptococcal preparation OK-432 on atopic dermatitis-like lesions in NC/Nga mice: possible shift from a Th2- to Th1-predominance

Journal of Dermatological Science
Y HoriuchiKiyoshi Nishioka

Abstract

The inducement of Th1 cell-mediated immune response, possibly brought about through bacterial stimulation, may serve to control atopic disorders such as atopic dermatitis (AD). The streptococcal preparation, OK-432, has been shown a potent Th1 inducer through the action of IL-12. NC/Nga mice under ordinary conditions have been found to contract dermatitis similar to human AD. Examination was made of the therapeutic effects of OK-432 local intra- and/or subcutaneous injections on AD-like lesions in NC/Nga mice. Immunohistochemical staining with IL-4/IL-12p40 and CD80/86 and phosphorylated STAT4/p-STAT6 and RT-PCR for IL-4/IL-12p40 and STAT6/STAT4 mRNA was conducted for the evaluation of OK-432 treatment of spontaneous AD-like lesions in NC/Nga mice. At 5 weeks following injection of OK-432, for treating head and back lesions in NC/Nga mice, 10 of 12 OK-432 treated NC mice were found to have clinically improved quite considerably. On the head and back skin of OK-432-treated mice, IL-12p40/CD80 positive cellular infiltration was conspicuous, in contrast to non-treated mice. IL-4/CD86 positive cellular infiltrates in OK-432-treated mice had decreased significantly more than in non-treated mice and IL-4 mRNA expression was virtually...Continue Reading

References

Jan 1, 1989·International Archives of Allergy and Applied Immunology·S RomagnaniM Ricci
Feb 1, 1996·European Journal of Immunology·F M RattisD Schmitt
Oct 31, 1996·Nature·A K AbbasA Sher
May 1, 1997·The Journal of Dermatology·S InuiK Yoshikawa
Jun 1, 1997·The British Journal of Dermatology·O OhkiK Nishioka
Apr 16, 1998·Japanese Journal of Pharmacology·J HiroiK Esaki
Apr 8, 1999·Thorax·I S Farooqi, J M Hopkin
Oct 19, 1999·The Journal of Clinical Investigation·C VestergaardK Matsushima
Jun 13, 2000·Oncogene·A L WursterM J Grusby

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Citations

May 8, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Patcharee RitprajakMiyuki Azuma
Mar 24, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Yusuke HaraMitsuru Sawa
Jul 16, 2005·The Journal of Dermatological Treatment·Y Horiuchi

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