Abstract
The inducement of Th1 cell-mediated immune response, possibly brought about through bacterial stimulation, may serve to control atopic disorders such as atopic dermatitis (AD). The streptococcal preparation, OK-432, has been shown a potent Th1 inducer through the action of IL-12. NC/Nga mice under ordinary conditions have been found to contract dermatitis similar to human AD. Examination was made of the therapeutic effects of OK-432 local intra- and/or subcutaneous injections on AD-like lesions in NC/Nga mice. Immunohistochemical staining with IL-4/IL-12p40 and CD80/86 and phosphorylated STAT4/p-STAT6 and RT-PCR for IL-4/IL-12p40 and STAT6/STAT4 mRNA was conducted for the evaluation of OK-432 treatment of spontaneous AD-like lesions in NC/Nga mice. At 5 weeks following injection of OK-432, for treating head and back lesions in NC/Nga mice, 10 of 12 OK-432 treated NC mice were found to have clinically improved quite considerably. On the head and back skin of OK-432-treated mice, IL-12p40/CD80 positive cellular infiltration was conspicuous, in contrast to non-treated mice. IL-4/CD86 positive cellular infiltrates in OK-432-treated mice had decreased significantly more than in non-treated mice and IL-4 mRNA expression was virtually...Continue Reading
References
May 1, 1976·Cancer·I KimuraY Urabe
Jul 1, 1992·The Journal of Clinical Investigation·M KiniwaG Delespesse
Jan 1, 1989·International Archives of Allergy and Applied Immunology·S RomagnaniM Ricci
Nov 1, 1995·The Journal of Experimental Medicine·S H GavettM Wills-Karp
Feb 1, 1996·European Journal of Immunology·F M RattisD Schmitt
Jul 11, 1996·Nature·M H KaplanM J Grusby
Oct 31, 1996·Nature·A K AbbasA Sher
Jan 3, 1997·Science·T ShirakawaJ M Hopkin
May 1, 1997·The Journal of Dermatology·S InuiK Yoshikawa
Jun 1, 1997·The British Journal of Dermatology·O OhkiK Nishioka
Aug 1, 1997·The Journal of Allergy and Clinical Immunology·T FujimuraK Nomoto
Apr 16, 1998·Japanese Journal of Pharmacology·J HiroiK Esaki
Aug 26, 1998·Immunology Today·M GreweJ Krutmann
Apr 8, 1999·Thorax·I S Farooqi, J M Hopkin
Oct 19, 1999·The Journal of Clinical Investigation·C VestergaardK Matsushima
Jun 13, 2000·Oncogene·A L WursterM J Grusby
Mar 7, 2001·Pediatrics·C GrüberUNKNOWN MAS-90 Study Group
Mar 10, 2001·The Journal of Allergy and Clinical Immunology·T KakinumaK Tamaki
Apr 11, 2001·The Journal of Allergy and Clinical Immunology·P ChristodoulopoulosQ Hamid
Jun 30, 2001·Journal of Anatomy·H NishioK Suzuki
Jul 27, 2001·Genomics·T HiroyamaH Nakauchi
Dec 1, 2001·Cancer Immunology, Immunotherapy : CII·M OkamotoM Sato
Jun 29, 2002·Journal of Dermatological Science·Mikiko OkadaHachiro Tagami
Feb 20, 2003·Journal of the National Cancer Institute·Masato OkamotoMitsunobu Sato
Citations
Jul 18, 2006·Archives of Dermatological Research·Yasuhiro HoriuchiMitsunobu Sato
May 8, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Patcharee RitprajakMiyuki Azuma
Sep 13, 2013·The Journal of Investigative Dermatology·Tae-Young LeeHaryoung Poo
Dec 5, 2008·Experimental Dermatology·Oystein GrimstadKouji Matsushima
Mar 24, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Yusuke HaraMitsuru Sawa
Jul 16, 2005·The Journal of Dermatological Treatment·Y Horiuchi
Nov 30, 2010·Innate Immunity·Naoki KoideTakashi Yokochi