Therapeutic effects of the angiogenesis inhibitor TNP-470 against carcinomatous peritonitis in mice

Anti-cancer Drugs
H TsujimotoJ Yamazaki

Abstract

The therapeutic effects of the new anti-angiogenesis factor TNP-470 were examined against carcinomatous peritonitis in mice. In the first experiment using carcinomatous peritonitis caused by i.p. inoculation of 10(6) M5076 tumor cells, TNP-470 solution was injected i.p. in a bolus of 50 mg/kg body weight into two groups of 10 mice either 1 or 8 days after the i.p. inoculation. The administration of TNP-470 on day 1 extended the survival time of the mice compared with 10 control mice receiving no treatment, whereas TNP-470 given on day 8 did not affect the survival time. In the next experiment on the M5076 tumor, TNP-470 solutions at 100 or 300 mg/kg were injected i.p. in a bolus into two groups of 20 mice 1 day after the inoculation 10(6) tumor cells, respectively. The administration of TNP-470 at 100 mg/kg also had an inhibitory effect. However, TNP-470 at 300 mg/kg caused toxic death in half of the mice. Next, we examined the effects of TNP-470 on another type of carcinomatous peritonitis model, which was caused by i.p. inoculation of 10(6) B16 melanoma cells. In this experiment, TNP-470 solutions in a bolus of 150 mg/kg were injected i.p. into six groups of 10 mice each on day 1 only (group 1), on days 1 and 4 (group 2), on ...Continue Reading

Citations

May 29, 1997·International Journal of Cancer. Journal International Du Cancer·T KanaiS Baba
Sep 25, 2003·Fertility and Sterility·Ying-Fang ZhouShinobu Sakamoto
Jul 5, 2001·Journal of the National Cancer Institute·A L FeldmanS K Libutti
Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·H TsujimotoT Takahashi
Nov 4, 2000·Expert Opinion on Investigational Drugs·E A Kruger, W D Figg
Jul 1, 1997·Antimicrobial Agents and Chemotherapy·E S Didier

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