Therapeutic efficacy and microSPECT/CT imaging of 188Re-DXR-liposome in a C26 murine colon carcinoma solid tumor model

Nuclear Medicine and Biology
Ya-Jen ChangGann Ting

Abstract

Nanocarriers can selectively target cancer sites and carry payloads, thereby improving diagnostic and therapeutic effectiveness and reducing toxicity. The objective of this study was to investigate the therapeutic efficacy of a new co-delivery radiochemotherapeutics of (188)Re-N,N-bis (2-mercaptoethyl)-N',N'-diethylethylenediamine (BMEDA)-labeled pegylated liposomal doxorubicin (DXR) ((188)Re-DXR-liposome) in a C26 murine colon carcinoma solid tumor model. To evaluate the targeting and localization of (188)Re-DXR-liposome in C26 murine tumor-bearing mice, biodistribution, microSPECT/CT imaging and pharmacokinetic studies were performed. The antitumor effect of (188)Re-DXR-liposome was assessed by tumor growth inhibition, survival ratio and histopathological hematoxylin-eosin staining. The tumor target and localization of the nanoliposome delivery radiochemotherapeutics of (188)Re-DXR-liposome were demonstrated in the biodistribution, pharmacokinetics and in vivo nuclear imaging studies. In the study on therapeutic efficacy, the tumor-bearing mice treated with bimodality radiochemotherapeutics of (188)Re-DXR-liposome showed better mean tumor growth inhibition rate (MGI) and longer median survival time (MGI=0.048; 74 days) than t...Continue Reading

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Citations

Dec 12, 2012·Investigational New Drugs·Ya-Jen ChangTe-Wei Lee
Mar 28, 2012·Annals of Nuclear Medicine·Chih-Hsien ChangKwo-Ping Chang
Jul 16, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Hao-Wen KaoHsin-Ell Wang
Aug 13, 2011·Cancer Biotherapy & Radiopharmaceuticals·Anuradha SoundararajanBeth A Goins
May 16, 2013·PloS One·Yi-Yu LinHsin-Ell Wang
May 1, 2013·International Journal of Nanomedicine·Jian-Xin ZhangSheng-Chun Dang
Jun 3, 2011·World Journal of Gastroenterology : WJG·Vera ArtikoVladimir Obradović
Jun 5, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Monique R BernsenMarion de Jong
Sep 3, 2010·Journal of Biomedicine & Biotechnology·Gann TingTe-Wei Lee
Jul 13, 2014·Advanced Drug Delivery Reviews·William T PhillipsBeth A Goins
Sep 11, 2012·Academic Radiology·Kelly Z AlvesJoão C Machado
Oct 29, 2011·Ultrasound in Medicine & Biology·Kelly Z AlvesJoão C Machado
Apr 27, 2012·Journal of Applied Toxicology : JAT·Liu Chi-MouLee Te-Wei
Oct 29, 2010·Journal of Applied Toxicology : JAT·Chi-Mou LiuTe-Wei Lee
Jul 19, 2012·Journal of Liposome Research·Andreas Tue Ingemann JensenPalle H Rasmussen
Apr 12, 2014·Regulatory Toxicology and Pharmacology : RTP·Si-Yen LiuTe-Wei Lee
Jun 24, 2017·Advanced Materials·Guosheng SongZhuang Liu
Dec 14, 2018·The Journal of Pharmacology and Experimental Therapeutics·Manisit Das, Leaf Huang
May 1, 2021·International Journal of Molecular Sciences·Chih-Hsien ChangGann Ting
Oct 29, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Liang-Ting LinYi-Jang Lee
Jul 30, 2020·Advanced Drug Delivery Reviews·Carlos Pérez-MedinaRoy van der Meel

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