Therapeutic efficacy of a herpes simplex virus with radiation or temozolomide for intracranial glioblastoma after convection-enhanced delivery.

Molecular Therapy : the Journal of the American Society of Gene Therapy
Costas G HadjipanayisNeal A DeLuca

Abstract

The herpes simplex virus-1 (HSV-1)-infected cell protein 0 (ICP0) is an E3 ubiquitin ligase implicated in cell cycle arrest and DNA repair inhibition. Convection-enhanced delivery (CED) of either the replication-defective, ICP0-producing HSV-1 mutant, d106, or the recombinant d109, devoid of all viral genome expression, was performed to determine the in vivo efficacy of ICP0 in combination with ionizing radiation (IR) or systemic temozolomide (TMZ) in the treatment of glioblastoma multiforme (GBM). Intracranial U87-MG xenografts were established in athymic nude mice. Animal survival was determined after mice underwent intracranial CED of either the replication-defective d106 or d109 viruses, or Hanks' balanced salt solution (HBSS), before a single session of whole-brain irradiation or TMZ treatment. Median survival for animals that underwent treatment with HBSS alone, d109 alone, d106 alone, HBSS + IR, HBSS + TMZ, d109 + IR, d106 + IR, and d106 + TMZ was 28, 35, 41, 39, 44, 39, 68 (P < 0.01), and 66 days (P < 0.01), respectively. Intracerebral d106 CED resulted in a significant increase in athymic nude mouse survival when combined with IR or TMZ. d106 CED allows for distribution of HSV-1 in human GBM xenografts and persistent v...Continue Reading

References

Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·R H BoboE H Oldfield
Jul 17, 1998·Journal of Neuroscience Methods·A I BrooksH J Federoff
Feb 2, 2000·Reviews in Medical Virology·J M MarkertR J Whitley
Aug 5, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R D Everett
Jan 6, 2001·Cell Transplantation·J CunninghamK S Bankiewicz
Jun 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sara A Jackson, Neal A DeLuca
Oct 2, 2003·Annals of Neurology·Juergen VogesAndreas H Jacobs
Oct 8, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ajay NiranjanJoseph C Glorioso
Dec 3, 2003·Journal of Neuro-oncology·Michael Weaver, Douglas W Laske
Feb 14, 2004·Journal of Virology·Ryan Hagglund, Bernard Roizman
Jun 15, 2004·Journal of Virology·Patrick LomonteAlberto L Epstein
Jan 22, 2005·Journal of Neurosurgery·David CroteauRussell R Lonser
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Mar 11, 2005·The New England Journal of Medicine·Lisa M DeAngelis
May 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Haidong GuBernard Roizman
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin H CohenRichard Pazdur
Jan 5, 2006·Journal of the National Cancer Institute·Manish AghiRobert L Martuza
Jul 1, 2006·Journal of Virology·Christine M Sanfilippo, John A Blaho
Mar 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandeep KunwarUNKNOWN Cintredekin Besudotox Intraparenchymal Study Group

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Citations

Jun 30, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jacqueline Nuss ParkerJames M Markert
Mar 30, 2011·Human Gene Therapy·Elspeth SmithBrian D Lichty
Feb 1, 2012·Drug Delivery and Translational Research·Mi Kyung YuSangyong Jon
Jan 23, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fatemeh PourgholiMehdi Yousefi
Jun 28, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yann TouchefeuKevin J Harrington
Jul 8, 2014·Frontiers in Microbiology·Jianfang Ning, Hiroaki Wakimoto
Jul 27, 2012·Journal of Biomaterials Applications·Imen MiladiMarc Janier
Oct 17, 2009·Expert Review of Neurotherapeutics·Waldemar Debinski, Stephen B Tatter
Nov 6, 2012·Expert Review of Clinical Pharmacology·Afshin SalehiBob S Carter
Dec 21, 2018·Frontiers in Oncology·John LynesEdjah Nduom
Apr 8, 2010·Molecular Cancer Therapeutics·Neal LutherMark M Souweidane
Jan 25, 2021·Advanced Drug Delivery Reviews·Taskeen Iqbal JanjuaAmirali Popat

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