Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Benin

Malaria Journal
A Ogouyèmi-HountoDorothée Kinde Gazard

Abstract

Artemether/lumefantrine (Coartem(®)) has been used as a treatment for uncomplicated Plasmodium falciparum infection since 2004 in Benin. This open-label, non-randomized study evaluated efficacy of artemether-lumefantrine (AL) in treatment of uncomplicated falciparum malaria in children aged 6-59 months in two malaria transmission sites in northwest Benin. A 42-day therapeutic efficacy study was conducted between August and November 2014, in accordance with 2009 WHO guidelines. One-hundred and twenty-three children, aged 6 months to 5 years, with uncomplicated falciparum malaria were recruited into the study. The primary endpoint was parasitological cure on day 28 and day 42 while the secondary endpoints included: parasite and fever clearance, improvement in haemoglobin levels. Outcomes were classified as early treatment failure (ETF), late clinical failure, late parasitological failure, and adequate clinical and parasitological response (ACPR). Before PCR correction, ACPR rates were 87% (95 % CI 76.0-94.7) and 75.6%, respectively (95% CI 67.0-82.9) on day 28 and day 42. In each study site, ACPR rates were 78.3% in Djougou and 73% in Cobly on day 42. There was no ETF and after PCR correction ACPR was 100% in study population. Al...Continue Reading

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Citations

Mar 28, 2018·The American Journal of Tropical Medicine and Hygiene·Zaydah R de LaurentEdwin Kamau
Jul 23, 2016·Parasite : Journal De La Société Française De Parasitologie·Aurore Ogouyèmi-HountoDorothée Kinde Gazard
Oct 21, 2020·The American Journal of Tropical Medicine and Hygiene·Matthew M IppolitoPhilip E Thuma
Mar 31, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Paulin SononEduardo A Donadi

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

Excel

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