Abstract
Artemether/lumefantrine (Coartem(®)) has been used as a treatment for uncomplicated Plasmodium falciparum infection since 2004 in Benin. This open-label, non-randomized study evaluated efficacy of artemether-lumefantrine (AL) in treatment of uncomplicated falciparum malaria in children aged 6-59 months in two malaria transmission sites in northwest Benin. A 42-day therapeutic efficacy study was conducted between August and November 2014, in accordance with 2009 WHO guidelines. One-hundred and twenty-three children, aged 6 months to 5 years, with uncomplicated falciparum malaria were recruited into the study. The primary endpoint was parasitological cure on day 28 and day 42 while the secondary endpoints included: parasite and fever clearance, improvement in haemoglobin levels. Outcomes were classified as early treatment failure (ETF), late clinical failure, late parasitological failure, and adequate clinical and parasitological response (ACPR). Before PCR correction, ACPR rates were 87% (95 % CI 76.0-94.7) and 75.6%, respectively (95% CI 67.0-82.9) on day 28 and day 42. In each study site, ACPR rates were 78.3% in Djougou and 73% in Cobly on day 42. There was no ETF and after PCR correction ACPR was 100% in study population. Al...Continue Reading
References
Jun 15, 1996·Lancet·R N PriceN J White
Feb 16, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·G SnounouS Viriyakosol
Feb 19, 2000·Antimicrobial Agents and Chemotherapy·F EzzetN J White
Jun 11, 2004·Tropical Medicine & International Health : TM & IH·Athanase NdayiragijeJean Kamana
Oct 1, 1996·Parasitology Today·N J White, P L Olliaro
Aug 30, 2006·Malaria Journal·Pascalina ChandaNaawa Sipilanyambe
Dec 16, 2006·Malaria Journal·William J CollinsGrant Dorsey
Jun 16, 2007·Malaria Journal·Babacar FayeOumar Gaye
Oct 18, 2008·Lancet·Salim AbdullaZulfikarali Premji
Oct 21, 2009·Malaria Journal·Zulfiqarali G Premji
Jan 7, 2010·Parasites & Vectors·Ashenafi AssefaTesfayae Mengesha
Feb 23, 2010·Malaria Journal·Solange Youdom WhegangLeonardo K Basco
Nov 26, 2010·Malaria Journal·Obaro S MichaelChristian T Happi
Dec 15, 2010·Parasites & Vectors·Anges YadoulétonMartin Akogbéto
Mar 1, 2011·Malaria Journal·Michael NamboziUmberto D'Alessandro
Mar 24, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Billy E NgasalaAndreas Mårtensson
May 24, 2011·Malaria Journal·Bertrand GrazAndré Rougemont
Aug 11, 2011·Malaria Journal·Jianping SongGuoqiao Li
Feb 14, 2012·Bulletin de la Société de pathologie exotique·D Kinde-GazardA Massougbodji
Jul 6, 2012·The American Journal of Tropical Medicine and Hygiene·Issaka SagaraAbdoulaye A Djimde
Dec 14, 2012·Malaria Journal·Roger C K TineOumar Gaye
Feb 7, 2013·Malaria Journal·Mathieu NdoungaPhilippe Brasseur
Jul 23, 2013·Malaria Journal·Birgit SchrammPhilippe J Guérin
Nov 15, 2013·Malaria Journal·Aurore Ogouyèmi-HountoAchille Massougbodji
Jan 8, 2014·Malaria Journal·Djibrine DjalléChristophe Rogier
Feb 6, 2014·Tropical Medicine & International Health : TM & IH·Halidou TintoUmberto D'Alessandro
Sep 23, 2014·Malaria Journal·Alex ShayoDeus S Ishengoma
Nov 19, 2014·Malaria Journal·Busiku HamainzaOlusegun Ayorinde Babaniyi
Apr 17, 2015·The Lancet Infectious Diseases·Michele D SpringDavid L Saunders
Aug 21, 2015·Malaria Journal·Paul SondoHalidou Tinto
Citations
Jun 24, 2016·Malaria Journal·Améyo M DorkenooPascal Ringwald
Feb 6, 2017·Tropical Medicine & International Health : TM & IH·Marian WarsameJamal Ghilan Hefzullah Amran
Mar 28, 2018·The American Journal of Tropical Medicine and Hygiene·Zaydah R de LaurentEdwin Kamau
Jul 13, 2019·Malaria Journal·Marian WarsamePascal Ringwald
Jul 17, 2019·Antimicrobial Agents and Chemotherapy·S JonesI Hastings
Jan 9, 2020·Pathogens and Global Health·Marius Trésor DableWilliam Yavo
Jun 26, 2020·Frontiers in Pharmacology·Qi WangChangsheng Deng
Jul 13, 2018·Malaria Journal·Celine I MandaraDeus S Ishengoma
Jul 23, 2016·Parasite : Journal De La Société Française De Parasitologie·Aurore Ogouyèmi-HountoDorothée Kinde Gazard
Oct 21, 2020·The American Journal of Tropical Medicine and Hygiene·Matthew M IppolitoPhilip E Thuma
Nov 5, 2020·Journal of Parasitology Research·Awoke DerbieTamrat Abebe
Mar 31, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Paulin SononEduardo A Donadi