Therapeutic efficacy of Ashwagandha against experimental aspergillosis in mice

Immunopharmacology and Immunotoxicology
J N Dhuley

Abstract

Therapeutic efficacy of an Indian Ayurvedic medicinal preparation, Ashwagandha [Withania somnifera L. Dunal (Solanceae; root)] was evaluated against experimental aspergillosis in Balb/c mice. Ashwagandha given orally once daily for 7 consecutive days in a dose of 100 mg/kg after intravenous infection of Aspergillus fumigatus prolonged the survival period of infected mice. This protective activity was probably related to the observed increases in phagocytosis and intracellular killing of peritoneal macrophages induced by Ashwaganda treatment. The number of peripheral leukocytes was not modified, excluding a possibility of mobilization of cells from other compartments. On the basis of these findings, the probable mechanism underlying the protective action of Ashwagandha against systemic Aspergillus infection was discussed in relation with its possible activity to activate the macrophage function.

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Citations

Dec 31, 2003·Journal of Ethnopharmacology·Sham DiwanayBhushan Patwardhan
Aug 13, 2008·Expert Opinion on Investigational Drugs·Scott MillerPatrick J Mansky
Apr 16, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M OwaisM Saleemuddin
Jun 15, 2016·Journal of Ayurveda and Integrative Medicine·Shruti B PatelLal L Hingorani
Sep 6, 2001·Phytotherapy Research : PTR·J N Dhuley
Apr 9, 2021·Journal of Ethnopharmacology·Vinod Kumar Joshi, Apurva Joshi
Oct 9, 1999·Clinical Microbiology Reviews·M M Cowan

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Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.