Therapeutic efficacy of chloroquine in Plasmodium vivax from areas with different epidemiological patterns in India and their Pvdhfr gene mutation pattern

Transactions of the Royal Society of Tropical Medicine and Hygiene
N ValechaPascal Ringwald

Abstract

Among the four human malaria parasites, drug resistance occurs mainly in Plasmodium falciparum. However, there are some reports of chloroquine (CQ) resistance in P. vivax from different geographical regions. In India, approximately 50% of a total of 2 million cases of malaria reported annually are due to P. vivax. CQ is the drug of choice for treatment. Since few cases of treatment failure have been reported from India, this study was undertaken to generate data systematically on the efficacy of CQ in 287 patients from different epidemiological regions. Cure rates for 28 days were 100% and there was a rapid parasite clearance rate in all age groups from all study sites. Although P. vivax has been reported to be inherently resistant to sulfonamide and pyrimethamine, Indian isolates exhibited only double mutations in dhfr in vitro.

References

Mar 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·G J SchuurkampK H Rieckmann
Mar 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·P L Garavelli, E Corti
Mar 28, 1991·The New England Journal of Medicine·I K SchwartzL C Patchen
Nov 18, 1989·Lancet·K H RieckmannD C Hutton
Jan 1, 1982·The American Journal of Tropical Medicine and Hygiene·B DarlowM Alpers
Nov 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene· Myat-Phone-Kyaw Nwe-Nwe-Yin
Nov 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·M GargN A Kshirsagar
Dec 1, 1996·Tropical Medicine & International Health : TM & IH·V K DuaV P Sharma
Jun 1, 1996·Journal of Travel Medicine·C AhlmH Carlsson
May 19, 2000·Antimicrobial Agents and Chemotherapy·S PukrittayakameeN J White
May 29, 2000·Annals of Tropical Medicine and Parasitology·N A KshirsagarM Wakde
Sep 7, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·R K Singh
Jun 14, 2003·Annals of Tropical Medicine and Parasitology·A NandyA K Bandyopadhyay
Oct 27, 2004·Antimicrobial Agents and Chemotherapy·J Kevin Baird
Apr 15, 2005·The New England Journal of Medicine·J Kevin Baird
Jul 11, 2007·Indian Pediatrics·Rajoo ThapaRitabrata Kundu

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Citations

Dec 30, 2006·Antimicrobial Agents and Chemotherapy·Mohammad Tauqeer AlamYagya D Sharma
Jul 15, 2009·Clinical Microbiology Reviews·J Kevin Baird
Apr 26, 2011·Malaria Journal·Surendra K PrajapatiVirendra K Dua
Sep 5, 2012·Malaria Journal·Ajay R BhartiNagalingeswaran Kumarasamy
Sep 13, 2011·Indian Journal of Pediatrics·Rajni Sharma, Ashok Kumar Dutta
Jan 24, 2012·Acta Tropica·Krishnamoorthy NarayanasamyPradipsinh K Rathod
Oct 16, 2007·Trends in Parasitology·J Kevin Baird
Mar 21, 2007·Trends in Parasitology·Vivian N HawkinsCarol Hopkins Sibley
Dec 10, 2014·Malaria Journal·Bilal Ahmad RahimiWatcharee Chokejindachai
May 28, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sekineh PirahmadiSedigheh Zakeri
Apr 12, 2008·Trends in Parasitology·Hema JoshiJane M Carlton
Oct 25, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mandana AfsharpadNavid D Djadid
Mar 30, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S K PrajapatiA P Dash
Oct 11, 2017·The American Journal of Tropical Medicine and Hygiene·Devendra BansalAli A Sultan
Jul 3, 2009·Current Opinion in Infectious Diseases·Ric N PriceNicholas M Anstey
Jul 9, 2011·The Korean Journal of Parasitology·Jalal ZamanMohammad Asgharzadeh
Oct 29, 2013·The Cochrane Database of Systematic Reviews·Gawrie N L GalappaththyRichard Kirubakaran
Jul 25, 2012·Paediatrics and International Child Health·Rajni SharmaAshok Kumar Dutta

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