Therapeutic efficacy of G207 in a novel peripheral nerve sheath tumor model

Experimental Neurology
G A MashourA Chalavi

Abstract

Nerve involvement poses a significant obstacle for the management of peripheral nervous system tumors, and nerve injury provides a frequent source of postoperative morbidity. The lack of suitable animal models for peripheral nerve tumors has impeded the development of alternative nerve-sparing therapies. To evaluate the effect of a multimutated replication-competent herpes simplex virus (G207) on the growth of peripheral nerve tumors and on nerve function, we developed a novel peripheral nerve sheath tumor model. Human neuroblastoma-derived cells injected into murine sciatic nerve consistently caused tumor development within the nerve sheath after 2 weeks followed by increasingly severe impairment of nerve function. Tumor treatment by a single intratumoral injection of G207 resulted in significant reduction of functional impairment, inhibition of tumor growth and prolonged survival. Direct injection of G207 viral particles into the healthy nerve sheath caused no obvious neurologic sequelae, whereas injections of wild-type virus resulted in uniform lethality. The results indicate that viral therapy might be considered as a safe alternative to surgical removal of tumors with peripheral nerve involvement.

References

Dec 1, 1990·Pediatric Dermatology·S J HayflickD L Dudgeon
Jul 1, 1994·Nature Genetics·T JacksR A Weinberg
Jan 1, 1993·Nature Genetics·I TheA Bernards
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M R JohnsonD R Lowy
Mar 1, 1997·Journal of Pediatric Hematology/oncology·G M BrodeurP S White
May 19, 1997·Biochemical and Biophysical Research Communications·K DäschnerH Kehrer-Sawatzki
Mar 25, 1998·Journal of Neurotrauma·P L Kuhn, J R Wrathall
May 18, 1999·Critical Reviews in Neurosurgery : CR·E FernandezR Pallini
Feb 16, 1999·Seminars in Surgical Oncology·G M HaaseJ B Atkinson
Nov 30, 1999·International Journal of Pediatric Otorhinolaryngology·E de CamporaL de Campora
Dec 11, 1999·Science·K CichowskiT Jacks
Dec 11, 1999·Science·K S VogelL F Parada
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·A JacobsC Fraefel

❮ Previous
Next ❯

Citations

Jan 14, 2010·Journal of the National Cancer Institute·Ziv GilRichard J Wong
Jul 7, 2007·Neurosurgical Focus·Deva S JeyaretnaRobert L Martuza
Nov 19, 2005·Nature Reviews. Cancer·Kelley A ParatoJohn C Bell
Jan 11, 2003·Cancer Gene Therapy·Susan Varghese, Samuel D Rabkin
Feb 1, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kaitlyn KellyZiv Gil
Nov 22, 2016·Expert Opinion on Orphan Drugs·Slawomir Antoszczyk, Samuel D Rabkin
Nov 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ziv GilRichard J Wong
Mar 4, 2005·The American Journal of Pathology·Shuqing LiuSusan L Cohn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.