Therapeutic efficacy of high-dose intravenous immunoglobulin in Mycobacterium tuberculosis infection in mice

Infection and Immunity
Eleanor RoyStephen Jolles


Intravenous immunoglobulin (IVIg) is used to treat patients with primary antibody deficiencies and, at high doses, to treat a range of autoimmune and inflammatory disorders. With high-dose IVIg (hdIVIg), immunomodulatory mechanisms act on a range of cells, including T cells, B cells, and dendritic cells. Here, we demonstrate that the treatment of M. tuberculosis-infected mice with a single cycle of hdIVIg resulted in substantially reduced bacterial loads in the spleen and lungs when administered at either an early or late stage of infection. Titration of the IVIg showed a clear dose-response effect. There was no reduction in bacterial load when mice were given equimolar doses of another human protein, human serum albumin, or maltose, the stabilizing agent in the IVIg preparation. HdIVIg in vitro had no inhibitory effect on the growth of M. tuberculosis in murine bone marrow-derived macrophages. In addition, the effect of hdIVIg on bacterial loads was not observed in nude mice, suggesting the involvement of conventional T cells. Analysis of T cells infiltrating the lungs revealed only small increases in CD8(+) but not CD4(+) T-cell numbers in hdIVIg-treated mice. The mechanism of action of hdIVIg against tuberculosis in mice rem...Continue Reading


Nov 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·A M CostelloC Moreno
Jan 1, 1989·Journal of Clinical Immunology·C Cunningham-Rundles
Oct 6, 1997·Brain : a Journal of Neurology·C M GabrielR A Hughes
Apr 1, 1998·Clinical and Diagnostic Laboratory Immunology·G HetlandM Harboe
May 16, 1998·Trends in Microbiology·A Casadevall
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·R TeitelbaumB R Bloom
Jun 11, 1999·Clinical and Experimental Immunology·W A SewellJ Farrant
Jul 22, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·C Cunningham-Rundles, C Bodian
Dec 4, 2002·Immunology·W A C Sewell, S Jolles
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenichi AkiyamaToshiyuki Takai
Jun 14, 2003·Critical Reviews in Immunology·Gabrielle T BelzWilliam R Heath
Jun 27, 2003·Drugs·W A Carrock SewellStephen R A Jolles
May 29, 2004·Trends in Pharmacological Sciences·Jagadeesh BayrySrini V Kaveri
Sep 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jagadeesh BayrySrini V Kaveri

❮ Previous
Next ❯


Apr 27, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Keertan DhedaYing Zhang
Feb 24, 2006·American Journal of Respiratory and Critical Care Medicine·Wing Wai Yew, Chi Chiu Leung
Jan 1, 2010·Infection and Drug Resistance·Justin T Denholm, Emma S McBryde
Nov 8, 2011·Infectious Disease Clinics of North America·Vidya SundareshanNancy Misri Khardori
Sep 29, 2011·Trends in Parasitology·David N A MekhaielRichard J Pleass
Aug 28, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Giuseppe LuziRaffaele D'Amelio
Nov 25, 2006·The Lancet Infectious Diseases·Rajko Reljic, Juraj Ivanyi
Mar 14, 2009·European Journal of Immunology·Paul J Maglione, John Chan
Feb 24, 2015·Immunological Reviews·Jacqueline M AchkarArturo Casadevall
Nov 21, 2009·Clinics in Chest Medicine·Gavin J ChurchyardGraham A Rook
Mar 19, 2013·Cell Host & Microbe·Jacqueline M Achkar, Arturo Casadevall
Mar 15, 2015·Nature Reviews. Immunology·Robert S Wallis, Richard Hafner
Dec 3, 2014·Seminars in Immunology·John ChanJoAnne Flynn
Jun 23, 2012·The American Journal of Pathology·Jia Yao PhuahJoAnne L Flynn
Jun 6, 2007·Expert Review of Anti-infective Therapy·Jacqueline M AchkarAharona Glatman-Freedman
Jul 17, 2009·Clinical and Experimental Immunology·F Abebe, G Bjune
Nov 21, 2017·Cellular & Molecular Immunology·Gucheng ZengXinchun Chen
Nov 4, 2016·EMBO Molecular Medicine·Natalie ZimmermannHedda Wardemann
Jan 25, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sucharitha BaluJuraj Ivanyi
Jul 23, 2013·Pathogens and Disease·Nesty OlivaresRogelio Hernandez-Pando
Sep 18, 2015·Oncotarget·Reto GulerFrank Brombacher
Jun 7, 2018·Nature Reviews. Immunology·Hao Li, Babak Javid
May 31, 2019·Frontiers in Immunology·Jeffrey Y KawaharaGalit Alter
Jan 11, 2020·Frontiers in Immunology·Milla R McLeanAmy W Chung
Apr 26, 2017·Proceedings of the National Academy of Sciences of the United States of America·Hao LiBabak Javid
Oct 22, 2020·European Journal of Immunology·Komal DolasiaSangita Mukhopadhyay
Mar 9, 2021·Frontiers in Immunology·Willemijn F RijninkSimone A Joosten

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.