PMID: 9420543Jan 8, 1998Paper

Therapeutic efficacy of interferon alfa-2b in infants with life-threatening giant hemangiomas

Archives of Dermatology
L TamayoR Ruiz-Maldonado

Abstract

Because of their size and the possibility of complications, giant hemangiomas represent a therapeutic challenge. Various forms of treatment have been used, with variable results, including surgery, embolization, lasers, pentoxifylline, and corticosteroids. Interferon alfa has been used successfully to treat life-threatening hemangiomas, possibly by means of its antiangiogenic activity. We treated 7 infants with organ-interfering and/or life-threatening giant hemangiomas with subcutaneous injections of 3 million U/m2 per day of interferon alfa-2b during the first month and subsequently every 48 to 72 hours, depending on the evolution in each case. The treatment lasted from 3 to 12 months. In 2 patients, interferon alfa-2b was administered while prednisone therapy was being tapered. In all 7 patients, there was considerable reduction of the volume of the hemangiomas and remission of their complications. All patients presented with fever, neutropenia, and an increase in serum aminotransferase levels. The patients who received interferon alfa-2b and prednisone seemed to improve at a faster rate. Interferon alfa-2b is a good option for the treatment of patients with steroid-resistant, organ-interfering and/or life-threatening giant ...Continue Reading

Citations

Aug 16, 2000·Pediatric Clinics of North America·M A DohilL F Eichenfield
Nov 19, 2002·Clinics in Dermatology·Edith OrionRonni Wolf
Dec 20, 2002·Clinics in Dermatology·Alex Zvulunov, Aryeh Metzker
Dec 18, 1998·Journal of Pediatric Hematology/oncology·C Fein-LevyA G Huvos
Dec 29, 2000·Journal of Pediatric Hematology/oncology·S A HurvitzM C Sanford
Jan 7, 2004·Plastic and Reconstructive Surgery·Arin K GreeneJohn B Mulliken
Jun 2, 2009·Plastic and Reconstructive Surgery·Daniel O Beck, Arun K Gosain
Jan 18, 2006·Journal of Pediatric Surgery·Sanjeev A VasudevanJed G Nuchtern
Oct 26, 2005·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Aline Cristina Batista Rodrigues JohannRicardo Alves Mesquita
Apr 10, 2007·Clinical Pediatrics·Michael J Sundine, Garrett A Wirth
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May 3, 2006·Medicinal Research Reviews·Ana R QuesadaMiguel A Medina
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Jun 23, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·R A SchwartzG Micali
Nov 11, 1999·Current Opinion in Pediatrics·J Powell

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