Therapeutic efficacy of platelet components treated with amotosalen and ultraviolet A pathogen inactivation method: results of a meta-analysis of randomized controlled trials

Vox Sanguinis
J CidM Lozano

Abstract

There are conflicting data regarding the therapeutic efficacy of platelets inactivated using amotosalen and ultraviolet A light. We have performed a meta-analysis to summarize the results of different randomized controlled trials (RCT). Five RCTs reported through March 2011 met the criteria for meta-analysis. Weighted mean difference (WMD) in corrected count increment (CCI) at 1 h, CCI-24 h, and transfusion interval (days) and summary odds ratio (OR) of bleeding in inactivated platelet (I-P) group vs. noninactivated platelet (C-P) group were calculated across studies. Randomized controlled trials were statistically homogeneous when we analysed CCI-24 h, and the transfusion of C-P was associated with a higher CCI-24 h when compared with the transfusion of I-P (WMD, 3×10(3); 95% CI, 2·32×10(3)-3·69×10(3); P<0·00001). RCTs were statistically heterogeneous when we analysed CCI-1 h, transfusion interval and OR of bleeding. Regarding the OR of bleeding in the I-P and C-P groups, it varied by as much as a multiple of four among the trials, from 0·66 to 2·66. When we combined double-blinded and high methodologic quality score RCTs, the use of I-P was not statistically associated with an increase in the OR of bleeding when compared with...Continue Reading

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Citations

May 28, 2013·Lancet·Lorna M Williamson, Dana V Devine
Oct 10, 2013·Current Opinion in Hematology·Miguel Lozano, Joan Cid
Apr 2, 2014·Transfusion Medicine Reviews·Michel PrudentLello Zolla
Apr 17, 2013·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·M Lozano, J Cid
May 29, 2013·British Journal of Haematology·Axel Seltsam, Thomas H Müller
Nov 9, 2012·Vox Sanguinis·C V Prowse
Jan 27, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Vishal SalunkheLaura Gutiérrez
Aug 1, 2016·La Presse médicale·Miguel Lozano, Joan Cid
Dec 8, 2015·Hematology·Ross M Fasano, Cassandra D Josephson
Nov 10, 2018·Hospital Practice·Stamatis J KarakatsanisKonstantinos N Syrigos
Aug 10, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Arno WieheMathias O Senge
Aug 2, 2017·The Cochrane Database of Systematic Reviews·Lise J EstcourtMichael F Murphy
Jun 22, 2018·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Markus JutziAndreas Buser
Jun 23, 2018·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Nov 16, 2019·Vox Sanguinis·Carlos GorriaMiguel Ángel Pérez Vaquero
Jun 3, 2021·Journal of Clinical Medicine·Annina CapraruBehrouz Mansouri Taleghani
Aug 20, 2021·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·S I HindawiE I Azhar

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