Therapeutic efficacy of targeting chemotherapy using local hyperthermia and thermosensitive liposome: evaluation of drug distribution in a rat glioma model

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
H AokiRyuichi Tanaka

Abstract

A method was developed of targeting chemotherapy using thermosensitive liposomes to treat malignant gliomas. Using the brain heating system, when the tumour core is heated to >43 degrees C, the tumour infiltrating zone is exposed to mild hyperthermia (40-43 degrees C). Thermosensitive liposomes were designed to release their contents at 40 degrees C to target both the tumour core and tumour infiltrating zone. The present study investigated the anti-tumour effect on rat glioma models in tumour drug uptake and tumour growth delay studies. Elevated accumulation of ADR in the rat C6 glioma after treatment was obtained in the area heated to >40 degrees C. However, there was no significant difference between the areas heated to 40-42 degrees C and >43 degrees C. Furthermore, it was found that ADR concentrations in the mildly hyperthermic areas were significantly higher following treatment with liposomal ADR than with free ADR. The animals treated with the new combination therapy had significantly longer overall survival time in comparison to those receiving other treatments. Thus, thermosensitive liposomes release their contents in response to mild hyperthermia and this combination therapy has a greater therapeutic efficacy for malig...Continue Reading

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Citations

Sep 1, 2007·Bioconjugate Chemistry·Elena V BatrakovaHoward E Gendelman
Jan 13, 2012·International Journal of Nanomedicine·Yan-li AnDong-sheng Zhang
Jun 7, 2006·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Ana M PonceMark W Dewhirst
May 25, 2012·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Anna Yudina, Chrit Moonen
Oct 17, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Mark W Dewhirst
Sep 9, 2005·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·L H LindnerM Peller
Jan 30, 2014·Drug Delivery·Narayanan KasinathanJ Venkata Rao
Feb 26, 2011·Expert Opinion on Drug Delivery·Elena V BatrakovaAlexander V Kabanov
Jul 25, 2008·Drug Development and Industrial Pharmacy·Pengyun ZengTimothy Scott Wiedmann
Jan 1, 2007·Progress in Polymer Science·A V Kabanov, H E Gendelman
Jan 26, 2008·Journal of Magnetic Resonance Imaging : JMRI·Roel DeckersChrit T W Moonen
Dec 2, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Grace H HuynhFrancis C Szoka
Sep 18, 2015·Chemotherapy Research and Practice·Matthew Trendowski
Jan 20, 2017·CNS Drugs·Mayur M Patel, Bhoomika M Patel

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