Therapeutic efficacy of zingerone against vancomycin-induced oxidative stress, inflammation, apoptosis and aquaporin 1 permeability in rat kidney

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Fatih Mehmet KandemirMuhammet Bahaeddin Dortbudak

Abstract

Vancomycin (VCM) is a glycopeptidic broad-spectrum antibiotic against methicillin-resistant Staphylococcus aureus, though it has some adverse effects, including nephrotoxicity, that limit its usefulness. Zingerone (ZO), a component of dry ginger root, has several pharmacological activities due to its antioxidant, anti-inflammatory and antiapoptotic properties. The aim of this study was to determine the therapeutic efficacy of ZO against VCM-induced oxidative stress, inflammation, apoptosis and kidney aquaporin 1 (AQP1) levels in rats. Intraperitoneal administration of VCM (200 mg/kg body weight) for seven days increased kidney lipid peroxidation and decreased antioxidant enzyme activities, including kidney superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). VCM increased serum creatinine and urea levels and induced histopathological changes while causing a decrease in AQP1 protein level. VCM also increased the levels of the inflammatory markers nuclear factor kappa B (NF-κB), B-cell lymphoma-3(Bcl-3), interleukin-1β (IL-1β), interleukin-33 (IL-33), tumor necrosis factor-α (TNF-α), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), myeloperoxidase (MPO) and cyclooxygenase-2 (COX-2). Moreove...Continue Reading

References

Jan 1, 1984·Methods in Enzymology·H Aebi
Oct 9, 2002·The American Journal of Pathology·Oscar López-FrancoCarmen Gómez-Guerrero
Oct 7, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D W King, M A Smith
Feb 22, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Nelson L RhodusFrank Ondrey
Oct 21, 2005·Basic & Clinical Pharmacology & Toxicology·Ilhami CelikH Handan Akbulut
Dec 19, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yogeshwer Shukla, Madhulika Singh
Aug 19, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gurdip SinghCesar A N Catalan
Oct 22, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christine DieterichHanna H Ng
Sep 14, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Mohamed H S Ahmida
Feb 1, 2011·Journal of Molecular Biology·Hui LiGregory A Voth
Oct 15, 2011·Electrolyte & Blood Pressure : E & BP·Sua KimGheun-Ho Kim
Dec 27, 2011·Molecular Cancer·Vilma Maldonado, Jorge Melendez-Zajgla
Feb 10, 2012·Human & Experimental Toxicology·Fatmagul BasarslanS Buyukbas
Mar 10, 2012·Free Radical Biology & Medicine·Yohei ArimuraRyozo Oishi
Mar 14, 2012·European Journal of Clinical Pharmacology·Sepideh ElyasiAmirhooshang Mohammadpour
Jul 24, 2012·The Journal of Nutritional Biochemistry·Pallavi ShrivastavaFakhrul Islam
Dec 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sung-Hwan KimHyoung-Chin Kim
Oct 1, 2014·Journal of Pharmacy Practice·Kari A Mergenhagen, Angela R Borton
Jan 13, 2015·Trends in Neurosciences·Alessandra BorsiniCarmine M Pariante
Jun 25, 2015·TheScientificWorldJournal·Bilal AhmadManzoor ur Rahman Mir
Oct 28, 2015·BioMed Research International·Blanca HumanesAlberto Lázaro
Feb 29, 2016·Pharmacological Reports : PR·Hany A OmarAbdel Nasser A M Elgendy
May 18, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ahmed AbdeenMasahiro Ikeda
May 21, 2016·Canadian Journal of Physiology and Pharmacology·Naglaa A BayomyReda H El-Bakary
Jul 6, 2016·International Neurourology Journal·Geun Ho ParkChang-Shin Park
Aug 22, 2016·Molecular and Cellular Biochemistry·Vijay ManiNalini Namasivayam
Oct 30, 2016·European Journal of Pharmacology·K L Hemalatha, P Stanely Mainzen Prince
Dec 13, 2016·Scientific Reports·Jinwen ChenDongshan Zhang
Jul 12, 2017·Molecular Cell·Vivien Ya-Fan WangGourisankar Ghosh

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Citations

Aug 28, 2019·Journal of Biochemical and Molecular Toxicology·Cüneyt Çağlayanİlhami Gulçin
Nov 13, 2019·Journal of Biochemical and Molecular Toxicology·Ping SuWang Lu
Jul 9, 2020·Molecular Biology Reports·Naila MalkaniMuhammad Imran Sohail
Aug 2, 2018·Biological Trace Element Research·Erdinç TurkMuslum Kuzu
Jun 6, 2019·Environmental Science and Pollution Research International·Fatih Mehmet KandemirGizem Eser
Jul 5, 2019·Environmental Science and Pollution Research International·Zeinab RafieeFereshteh Nejad-Dehbashi
Mar 14, 2019·Drug and Chemical Toxicology·Sevda GuzelBanu Coskun Yilmaz
Aug 24, 2019·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Cuneyt CaglayanMuhammet Bahaeddin Dortbudak
Dec 5, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yiyou LinChangyu Li
Feb 19, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Fatih Mehmet KandemirMuhammet Bahaeddin Dortbudak
May 15, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chen GaoZhihui Hao
Sep 2, 2021·Brazilian Journal of Biology = Revista Brasleira De Biologia·N EhsanS Mahboob
Jan 18, 2022·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Selim ÇomaklıSelçuk Özdemir

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