Therapeutic efficacy test in malaria falciparum in Antioquia, Colombia

Malaria Journal
S BlairA Tobón

Abstract

Evaluate the frequency of failure of eight treatments for non-complicated malaria caused by Plasmodium falciparum in patients from Turbo (Urabá region), El Bagre and Zaragoza (Bajo Cauca region), applying the 1998 protocol of the World Health Organization (WHO). Monotherapies using chloroquine (CQ), amodiaquine (AQ), mefloquine (MQ) and sulphadoxine-pyrimethamine (SP), and combinations using chloroquine-sulphadoxine-pyrimethamine (CQ-SP), amodiaquine-sulphadoxine-pyrimethamine (AQ-SP), mefloquine-sulphadoxine-pyrimethamine (MQ-SP) and artesunate-sulphadoxine-pyrimethamine (AS-SP), were examined. A balanced experimental design with eight groups. Samples were selected based on statistical and epidemiological criteria. Patients were followed for 21 to 28 days, including seven or eight parasitological and clinical evaluations, with an active search for defaulting patients. A non-blinded evaluation of the antimalarial treatment response (early failure, late failure, adequate response) was performed. Initially, the loss of patients to follow-up was higher than 40%, but the immediate active search for the cases and the monetary help for transportation expenses of patients, reduced the loss to 6%. The treatment failure was: CQ 82%, AQ ...Continue Reading

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Citations

Dec 25, 2009·International Journal for Equity in Health·Obinna OnwujekweOgoamaka Chukwuogo
Oct 31, 2007·Expert Opinion on Drug Safety·Harry K TagborBrian Greenwood
Apr 3, 2013·The American Journal of Tropical Medicine and Hygiene·Jaime Carmona-FonsecaAmanda Maestre
Jul 28, 2017·The American Journal of Tropical Medicine and Hygiene·Maria Arroyo-ArroyoAmanda Maestre
Jul 10, 2009·The Cochrane Database of Systematic Reviews·David SinclairPaul Garner
Sep 29, 2011·Experimental Parasitology·Sarika YadavU N Dwivedi

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Methods Mentioned

BETA
pregnancy test

Software Mentioned

EpiInfo
CL
AQ
Turbo
AFESS
SP
MQ
SPSS

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