PMID: 9555595Apr 29, 1998Paper

Therapeutic equivalence of risperidone given once daily and twice daily in patients with schizophrenia. The Risperidone Study Group

Journal of Clinical Psychopharmacology
N P Nair

Abstract

A study was conducted to determine whether once-daily administration of risperidone was as effective and safe as twice-daily administration. In a double-blind 6-week trial, 211 patients with acute exacerbation according to DSM-III-R criteria were randomly assigned to receive risperidone at 8 mg once daily or 4 mg twice daily. The primary efficacy measure was the treatment response rate, defined as a 20% or greater reduction in total Positive and Negative Syndrome Scale (PANSS) scores. Severity of extrapyramidal symptoms was assessed by the Extrapyramidal Symptom Rating Scale. The percentage of patients who showed a treatment response at endpoint was not significantly different between groups (76%, once-daily; 72%, twice-daily), nor was the median time to first treatment response (14 days, both groups). Significant reductions in PANSS total and subscale scores and PANSS-derived Brief Psychiatric Rating Scale were observed in both groups, with no significant between-group differences. Extrapyramidal Symptom Rating Scale scores did not differ significantly between groups. There were no clinically relevant changes in vital signs, electrocardiograms, or clinical laboratory test results in either group. Gradual dosage titration over ...Continue Reading

Associated Clinical Trials

References

Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Dec 1, 1982·Controlled Clinical Trials·W C Blackwelder
Jun 1, 1994·The American Journal of Psychiatry·S R Marder, R C Meibach
Sep 1, 1993·Clinical Pharmacology and Therapeutics·M L HuangJ H Jonkman

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Citations

Dec 31, 2002·Controlled Clinical Trials·Geert MolenberghsAriel Alonso
Dec 31, 2002·Psychoneuroendocrinology·R Tandon, M D Jibson
Mar 14, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·M C MauriP Papa
Jul 14, 2000·Current Medical Research and Opinion·B Green
Dec 2, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Celso ArangoDolores Maria Moreno
Jul 28, 2012·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Alkomiet HasanUNKNOWN World Federation of Societies of Biological Psychiatry (WFSBP) Task Force on Treatment Guidelines for Schizophrenia
Feb 5, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Hiroyoshi TakeuchiGary Remington
Sep 22, 2005·Journal of Psychopharmacology·Niina Ezewuzie, David Taylor
Feb 19, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Julie A Dopheide
Nov 5, 2002·Journal of Biopharmaceutical Statistics·Ariel AlonsoTony Vangeneugden
Mar 23, 2021·Schizophrenia Bulletin·Hiroyoshi TakeuchiGary Remington

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