Therapeutic evaluation of interleukin 1-beta antagonist Anakinra against traumatic brain injury in rats

Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES
Askin E HasturkOya Evirgen

Abstract

The aim of this study was to evaluate the therapeutic efficiency of Anakinra, an IL-1ß antagonist with anti-inflammatory effects, in an experimental model of traumatic brain injury (TBI). Fifty-four rats underwent TBI after a weighted object was dropped onto a metal disc secured to their skulls. Animals were randomized into 3 main groups: control (n=18), TBI + saline (n=18; six animals per time-point) with samples obtained at the first, sixth and twenty-fourth h postoperatively, and TBI + Anakinra (n=18; six animals per time-point) with brain samples obtained at the first, sixth and twenty-fourth h postoperatively. Brain tissue and blood serum were extracted for the analysis of IL-1ß, malondialdehyde, glutathione peroxidase, superoxide dismutase, and catalase levels. Tissue sections were evaluated histopathologically under a light microscope. After trauma, tissue and serum IL-1ß levels were significantly elevated and after Anakinra administration, these levels substantially decreased. Glutathione peroxidase, superoxide dismutase, and catalase activity decreased following TBI and Anakinra administration proved effective in increasing the activity of these antioxidant enzymes. Histopathological analysis confirmed that Anakinra mi...Continue Reading

Citations

Jun 5, 2016·Brain Injury : [BI]·Peter P SordilloLawrence Helson
Oct 28, 2016·The Journal of Obstetrics and Gynaecology Research·Umit Arslan NaykiIsmail Malkoc
Jul 10, 2018·The Journal of Trauma and Acute Care Surgery·Bobby Darnell RobinsonBinu Tharakan
Dec 4, 2019·Experimental Animals·Fatih OzcicekHalis Suleyman
Dec 19, 2019·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Yasin Duran, İhsan Karaboğa
Jun 8, 2021·Neural Plasticity·Xin HuangLiang Wen

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