PMID: 9180600May 1, 1997Paper

Therapeutic evaluation of two different dose regimens of praziquantel in a recent Schistosoma mansoni focus in Northern Senegal

The American Journal of Tropical Medicine and Hygiene
F GuisséB Gryseels

Abstract

A therapeutic trial, involving 130 Schistosoma mansoni-infected children, with no previous history of antischistosomal treatment, was carried out to evaluate the efficacy of two different dose regimens of praziquantel. The study was carried out because low cure rates were described in this recently established (1990) S. mansoni focus in northern Senegal, following treatment with a standard dosage of 40 mg/kg. The subjects were randomly allocated into two groups: one group (1) received 40 mg/kg in one oral dose, the other group (2) was treated with two oral doses of 30 mg/kg at a 6-hr interval. Parasitologic examination and circulating anodic antigen (CAA) detection were performed before, 10 days, three, six, and 21 weeks after chemotherapy. No significant differences in cure rates were found between the two groups. Six weeks after treatment, 34% and 44% of the individuals were found to be stool negative in group 1 and group 2, respectively. However, only 10-15% became completely negative according to the serum CAA antigen assay. Mean egg counts were reduced by 99% in both groups. Antigen detection confirmed the parasitologic results. Fewer side effects were observed in the group treated with 2 x 30 mg/kg, which may be explained...Continue Reading

Citations

Aug 6, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·M PicquetA Ly
Dec 21, 2000·Tropical Medicine & International Health : TM & IH·J UtzingerM Tanner
May 21, 2015·PLoS Neglected Tropical Diseases·Alessandra GuidiQuentin D Bickle
Apr 7, 2006·Expert Review of Anti-infective Therapy·Michael J Doenhoff, Livia Pica-Mattoccia
Nov 4, 2008·Current Opinion in Infectious Diseases·Michael J DoenhoffJürg Utzinger
Apr 13, 2013·Memórias do Instituto Oswaldo Cruz·Kentaro KatoYoshinori Mitsui
Mar 2, 2013·The Cochrane Database of Systematic Reviews·Anthony Danso-AppiahJürg Utzinger
Jul 20, 2019·CNS Drugs·Madison K Bangert, Rodrigo Hasbun
Sep 14, 2001·Tropical Medicine & International Health : TM & IH·Y S LiangG C Coles
Dec 12, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·Michael J DoenhoffDonato Cioli
Feb 15, 2000·Tropical Medicine & International Health : TM & IH·Y S LiangM J Doenhoff
Apr 20, 2002·Current Opinion in Infectious Diseases·Donato Cioli
Aug 17, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·N B KabatereineB J Vennnervald
Aug 1, 2015·Clinical Microbiology Reviews·Kosala G A D WeerakoonDonald P McManus
Oct 1, 2007·Expert Opinion on Drug Discovery·Sanaa S Botros, James L Bennett
Jul 20, 2004·Annals of Tropical Medicine and Parasitology·P C Inyang-EtohE C Inyang-Etoh
Mar 31, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·L A Tchuem TchuentéB Gryseels
Oct 30, 2020·Infection and Drug Resistance·Asmaa M El-KadyAlzahraa Abdelraouf Ahmad
Dec 4, 2001·International Journal for Parasitology·J UtzingerM Tanner
Feb 7, 2001·Clinical Microbiology Reviews·S Geerts, B Gryseels
Jul 26, 2011·Biochimica Et Biophysica Acta·Stefanie Prast-NielsenDavid L Williams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.