Therapeutic gene delivery to the skin

Molecular Medicine Today
P A Khavari

Abstract

The skin represents a site for treatment of cutaneous and systemic disease and is the most accessible somatic tissue for therapeutic gene transfer in humans. Monogenic hereditary skin diseases, such as ichthyosis and epidermolysis bullosa subtypes, and disorders characterized by low levels of polypeptides in the systemic circulation, are current central foci of efforts in cutaneous-gene transfer. Additional efforts center on the treatment of wounds and malignancies. Recent developments in models of gene delivery to the skin underscore key challenges that must be met before successful treatment of human disease by cutaneous gene delivery can be achieved.

References

Oct 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·D L BerlinerR M Lavker
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·E S FenjvesL B Taichman
Oct 1, 1987·Plastic and Reconstructive Surgery·C B CuonoJ McGuire
Aug 16, 1984·The New England Journal of Medicine·G G GallicoH Green
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·N NaffakhY Beuzard
Jan 13, 1995·Cell·P H JonesF M Watt
Jul 1, 1994·The Journal of Burn Care & Rehabilitation·J F HansbroughL Wilkins
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·C AndreeE Eriksson
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J M CarrollL B Taichman
Nov 1, 1993·Archives of Dermatology·J C Vogel
Feb 1, 1993·Nature Genetics·A J GerrardF M Watt
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·L ChengN S Yang
Jan 1, 1996·Life Sciences·I R Williams, T S Kupper
Jun 15, 1996·The Journal of Clinical Investigation·U R HenggeJ C Vogel
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·A L RakhmilevichN S Yang
May 20, 1996·Human Gene Therapy·I F CiernikD P Carbone
Nov 1, 1996·Nature Medicine·K A ChoateP A Khavari
Dec 1, 1996·Human Gene Therapy·K A ChoateP A Khavari
Dec 15, 1996·The Journal of Clinical Investigation·S I BennJ M Davidson
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·X WangE Fuchs
Jan 1, 1997·Dermatologic Clinics·P A Khavari, G G Krueger
Jun 1, 1997·Human Molecular Genetics·R A FreibergP A Khavari
Jun 1, 1997·Nature Medicine·H Blau, P Khavari
May 20, 1997·Human Gene Therapy·K A Choate, P A Khavari
Jan 7, 1998·Nature Biotechnology·H DengP A Khavari

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Citations

Sep 21, 2000·Pharmaceutical Science & Technology Today·A NaikR H Guy
Jun 21, 2002·Journal of Internal Medicine·P A KhavariA Vahlquist
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·W PfutznerJ C Vogel
Feb 25, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Amla Chopra, Gregor Cevc
Apr 16, 1998·The Journal of Investigative Dermatology·P A Khavari
Dec 22, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marianna FoldvariAmirreza Rafiee
Dec 17, 2005·International Journal of Pharmaceutics·Babu M Medi, Jagdish Singh
Nov 9, 2005·Burns : Journal of the International Society for Burn Injuries·Bishara S AtiyehS William Gunn
Sep 1, 2004·Expert Opinion on Biological Therapy·Sabine A EmingJeffrey M Davidson
May 10, 2007·Journal of Biomedicine & Biotechnology·Frank JacobsenLars Steinstraesser
Nov 4, 2000·Expert Opinion on Investigational Drugs·W Pfützner, J C Vogel
Jan 31, 2002·Plastic and Reconstructive Surgery·Oren M Tepper, Babak J Mehrara
Jan 18, 2005·World Journal of Surgery·Bishara S AtiyehShady N Hayek
Jul 23, 2021·Advanced Drug Delivery Reviews·Ming ZengWenxin Wang

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