Therapeutic hypothermia after cardiac arrest

Current Opinion in Anaesthesiology
Michael Holzer, W Behringer

Abstract

Most patients who suffer a cardiac arrest die after the event. Full neurological recovery occurs in only 6-23%. Until recently no specific post-arrest therapy was available to improve outcome. Application of therapeutic hypothermia (32-34 degrees C for 12-24 h) applied after cardiac arrest could help to improve this dreadful situation. This review covers the background of and recent clinical studies into hypothermia after cardiac arrest, and gives some insights into the future of resuscitation, namely suspended animation. Two randomized clinical trials of mild therapeutic hypothermia applied after successful resuscitation from cardiac arrest showed that hypothermia after cardiac arrest improves neurological outcome as well as overall mortality. The introduction of therapeutic hypothermia after cardiac arrest into routine intensive care practice could save thousands of lives worldwide, because only six patients must be treated to yield one additional patient with favourable neurological recovery. New developments in cooling techniques will make early induction of therapeutic hypothermia simple and convenient. The optimal duration and depth of hypothermia will be determined by future trials. Suspended animation is cooling during ...Continue Reading

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Citations

Jun 13, 2006·AACN Advanced Critical Care·Mary Holden, Mary Beth Flynn Makic
Feb 9, 2010·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Anders Rostrup NakstadKristina Hermann Haugaa
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Sep 23, 2014·Iranian Red Crescent Medical Journal·Hassan SoleimanpourSamad Ej Golzari
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