Nov 20, 2012

Therapeutic hypothermia application vs standard support care in post resuscitated out-of-hospital cardiac arrest patients

The American Journal of Emergency Medicine
Chieh-Jen WangChien-Liang Wu

Abstract

Survival after cardiac arrest remains poor, especially when it occurs outside of hospital. In recent years, therapeutic hypothermia has been used to improve outcomes in patients who have experienced cardiac arrest, however, application to out-of-hospital cardiac arrest (OHCA) patients remains controversial. A total of 175 OHCA patients underwent therapeutic hypothermia (TH), which was performed using large volume ice crystalloid fluid (LVICF) infusions after ICU admission. Ice packs and conventional cooling blankets were used to maintain a core body temperature of 33°C, according to standard protocol for 36 hours. Patients in the control group received standard supportive care without TH. Hospital survival and neurologic outcomes were compared. There was no significant difference between the groups with regards to patient characteristics, underlying etiologies, and length of hospital stays. The duration of cardiac pulmonary resuscitation (CPR) was also similar. In the 51 patients that received TH, 14 were alive at hospital discharge. In the 124 patients belonging to the supportive care group, only 15 were alive at hospital discharge (27.5% vs. 12.1%, p = 0.013). Approximately 7.9% of patients in the TH group had good neurologic...Continue Reading

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References

  • References19
  • Citations7

Citations

Mentioned in this Paper

Acrocallosal Syndrome
Ventricular Fibrillation
Disseminated Intravascular Coagulation
Lung
Muscle relaxants FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Basic Cardiac Life Support
Crystalloid
Sleep Disorders, Circadian Rhythm
Etiology
Combined Modality Therapy

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