Jul 2, 2014

Therapeutic hypothermia for neuroprotection: history, mechanisms, risks, and clinical applications

The Neurohospitalist
Lioudmila V KarnatovskaiaWilliam D Freeman


The earliest recorded application of therapeutic hypothermia in medicine spans about 5000 years; however, its use has become widespread since 2002, following the demonstration of both safety and efficacy of regimens requiring only a mild (32°C-35°C) degree of cooling after cardiac arrest. We review the mechanisms by which hypothermia confers neuroprotection as well as its physiological effects by body system and its associated risks. With regard to clinical applications, we present evidence on the role of hypothermia in traumatic brain injury, intracranial pressure elevation, stroke, subarachnoid hemorrhage, spinal cord injury, hepatic encephalopathy, and neonatal peripartum encephalopathy. Based on the current knowledge and areas undergoing or in need of further exploration, we feel that therapeutic hypothermia holds promise in the treatment of patients with various forms of neurologic injury; however, additional quality studies are needed before its true role is fully known.

  • References75
  • Citations32


  • References75
  • Citations32


Mentioned in this Paper

Brain Injuries
Malignant Neoplasm of Spinal Cord
Neoplasm of Uncertain or Unknown Behavior of Spinal Cord
Hepatic Encephalopathy
Spinal Cord Diseases
Benign Neoplasm of Spinal Cord
Entire Body System
Intracranial Pressure
Brain Damage, Chronic

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

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