Therapeutic hypothermia for out-of-hospital cardiac arrest

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Rozalynne Lee, Kwame Asare

Abstract

The use of therapeutic hypothermia (TH) and its application in out-of-hospital cardiac arrest patients are reviewed. Each year in the United States, an estimated 250,000-300,000 out-of-hospital cardiac arrests occur. Despite advances in prehospital care, the survival rate from TH is only 6-12%. In addition, survivors often have devastating consequences ranging from mild memory impairment to permanent brain damage. It is presumed that early induction of hypothermia produces an optimal effect, though benefits can still be achieved with late induction. Several methods have been devised to induce hypothermia, yet the optimal methods of cooling have not currently been determined. Major adverse effects of cooling include hemodynamic changes, cardiovascular complications, hyperglycemia, coagulopathy, increased rates of infection, fluid and electrolyte disorders, and shivering. The majority of these adverse effects can be prevented or minimized in the intensive care setting. In 2002, the use of TH--cooling the core body temperature to 32-34 degrees C--was supported by two landmark human studies, whose results led to the endorsement of TH by the American Heart Association and its increased use. The studies demonstrated that hypothermia ...Continue Reading

References

Oct 1, 1978·Annals of Internal Medicine·J B Reuler
Sep 1, 1991·The American Journal of Emergency Medicine·M AngelosH Reich
Nov 1, 1987·Journal of the American College of Cardiology·S E BashD M Geiss
Feb 20, 1997·The New England Journal of Medicine·D W MarionS T DeKosky
Feb 16, 1999·Archives of Internal Medicine·R de VosR J de Haan
Mar 10, 1999·Cardiovascular Research·S L Hale, R A Kloner
Oct 20, 1999·Journal of Neurosurgical Anesthesiology·P A IaizzoD C Sigg
Dec 22, 1999·Progress in Cardiovascular Diseases·D L SmallA M Buchan
Oct 30, 2001·Anesthesia and Analgesia·M MokhtaraniD I Sessler
Dec 12, 2001·Resuscitation·S Hachimi-IdrissiL Huyghens
Jan 17, 2002·The New England Journal of Medicine·G van den BergheR Bouillon
Feb 22, 2002·The New England Journal of Medicine·UNKNOWN Hypothermia after Cardiac Arrest Study Group
Feb 22, 2002·The New England Journal of Medicine·Stephen A BernardKaren Smith
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Michael W DaeCarol A Stillson
Jul 10, 2002·Stroke; a Journal of Cerebral Circulation·R KollmarS Schwab
Mar 5, 2003·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Jason StonerMichael Tomlanovich
Apr 12, 2003·Stroke; a Journal of Cerebral Circulation·Anthony G DoufasDaniel I Sessler
Apr 30, 2003·Journal of Clinical Anesthesia·Simone Maria D'Angelo VanniGeraldo Rolim Rodrigues
Jul 9, 2003·Critical Care Medicine·Stephen A Bernard, Michael Buist
May 1, 1954·A.M.A. Archives of Surgery·C K KIRBYJ JOHNSON
Jul 1, 1954·The American Journal of Physiology·A H HEGNAUER, H E D'AMATO
Aug 21, 1954·Lancet·E G BREWIN
Jun 5, 2004·The Journal of Trauma·Amanda M LairdMichael C Chang
Oct 29, 2004·Critical Care Medicine·Menekhem M ZvimanHenry R Halperin
Apr 27, 2005·Brain Research. Brain Research Reviews·Oliver I SchmidtPhilip F Stahel

❮ Previous
Next ❯

Citations

Aug 17, 2011·Nursing·Jacqueline Harden
Dec 12, 2012·Dimensions of Critical Care Nursing : DCCN·Jenny Jolley, Roy Ann Sherrod
Dec 8, 2011·Clinical Nurse Specialist CNS·Emily Beddingfield, Angela P Clark
Oct 3, 2014·BioMed Research International·S IrvingA K Wise
Oct 29, 2014·Critical Care : the Official Journal of the Critical Care Forum·Azurahisham Sah PriThomas Desaive
Mar 12, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Mohi E AlkadriChristopher J White
Apr 17, 2015·Critical Care : the Official Journal of the Critical Care Forum·Sang Hoon OhUNKNOWN Korean Hypothermia Network Investigators
Jun 11, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Denijal TopcicKarlheinz Peter
Jun 4, 2016·Dimensions of Critical Care Nursing : DCCN·Jessica Wyse, Molly McNett
Dec 4, 2019·Dimensions of Critical Care Nursing : DCCN·Thomas Alne
Dec 25, 2012·The Nurse Practitioner·Linda BucherSusan Treseder
Jan 18, 2012·Critical Care Medicine·Robert I Parker
Dec 12, 2012·Nursing·Linda BucherSusan Treseder
Apr 11, 2013·Dimensions of Critical Care Nursing : DCCN·Linda BucherSusan Treseder
Jul 9, 2021·Biochemical and Biophysical Research Communications·Daiki JinguHiroshi Ohnishi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.