Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children.

Critical Care Medicine
Hülya BayirPatrick M Kochanek

Abstract

Oxidative stress contributes to secondary damage after traumatic brain injury (TBI). Hypothermia decreases endogenous antioxidant consumption and lipid peroxidation after experimental cerebral injury. Our objective was to determine the effect of therapeutic hypothermia on oxidative damage after severe TBI in infants and children randomized to moderate hypothermia vs. normothermia. Prospective randomized controlled study. Pediatric intensive care unit of Pittsburgh Children's Hospital. The study included 28 patients. We compared the effects of hypothermia (32 degrees C-33 degrees C) vs. normothermia in patients treated in a single center involved in a multicentered randomized controlled trial of hypothermia in severe pediatric TBI (Glasgow Coma Scale score <or=8). The patients randomized to hypothermia (n = 13) were cooled to target temperature within approximately 6 to 24 hours for 48 hours and then rewarmed. Antioxidant status was assessed by measurements of total antioxidant reserve and glutathione. Protein oxidation and lipid peroxidation were assessed by measurements of protein thiols and F2-isoprostane, respectively, in ventricular cerebrospinal fluid (CSF) samples (n = 76) obtained on day 1-3 after injury. The association...Continue Reading

References

Nov 1, 1992·Journal of Neurochemistry·B Halliwell
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J D MorrowL J Roberts
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R BustoM D Ginsberg
Oct 1, 1965·Archives of Neurology·H L RosomoffJ Bebin
Apr 1, 1993·Molecular and Chemical Neuropathology·B G LyethL W Jenkins
Aug 21, 1996·JAMA : the Journal of the American Medical Association·B YoungJ W Kupiec
Feb 20, 1997·The New England Journal of Medicine·D W MarionS T DeKosky
Jun 17, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E H SinzD W Marion
Dec 23, 1998·Scandinavian Cardiovascular Journal : SCJ·P RainioK J Peuhkurinen
Mar 21, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K ChatzipanteliW D Dietrich
Nov 4, 2000·Journal of Neurotrauma·A LewénP H Chan
Feb 24, 2001·The New England Journal of Medicine·G L CliftonM Schwartz
Aug 31, 2001·Journal of Neurotrauma·H A KasprzakB Woźniak
Jan 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Wilhelm BehringerSamuel A Tisherman
Feb 22, 2002·The New England Journal of Medicine·UNKNOWN Hypothermia after Cardiac Arrest Study Group
Feb 22, 2002·The New England Journal of Medicine·Stephen A BernardKaren Smith
Mar 7, 2002·British Journal of Anaesthesia·A K GuptaP J Kirkpatrick
May 29, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maria ErecinskaIan A Silver
Jun 14, 2003·Journal of Neurotrauma·Pichuan FanDonna M Ferriero
Jun 19, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Patrick M. KochanekLarry W. Jenkins
Jul 9, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·P David AdelsonUNKNOWN World Federation of Pediatric Intensive and Critical Care Societies
Jul 9, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·P David AdelsonUNKNOWN World Federation of Pediatric Intensive and Critical Care Societies
Aug 30, 2003·Neuroscience Letters·Julie G PilitsisJohn W Phillis
Feb 28, 2004·Journal of Neurotrauma·Hülya BayirPatrick M Kochanek
Aug 17, 2004·Journal of Cardiovascular Pharmacology and Therapeutics·Boris Z SimkhovichRobert A Kloner

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Citations

Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ananda P Sen, Anil Gulati
Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Pramod K DashAnthony N Moore
Jul 1, 1997·Medical Hypotheses·C M David
Jul 25, 2009·Antioxidants & Redox Signaling·Rao Muralikrishna Adibhatla, James Franklin Hatcher
Jan 18, 2011·Antioxidants & Redox Signaling·Ying XiongDanyelle M Townsend
Mar 1, 2012·Therapeutic Hypothermia and Temperature Management·Patrick M KochanekMichael J Bell
Feb 1, 2011·Brain : a Journal of Neurology·Axel PetzoldMartin Smith
Mar 28, 2009·Critical Care Medicine·Douglas D Fraser, Gavin Morrison
Sep 4, 2009·Current Opinion in Pediatrics·Mioara D ManoleRobert S B Clark
Apr 7, 2011·Current Opinion in Pediatrics·Joshua D Koch, Steven G Kernie
Feb 9, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Melissa M Guerra-WallaceRobert W Hickey
Feb 27, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Bhavani P ThampattySamuel M Poloyac
Nov 3, 2011·Neurosurgical Focus·Geoffrey AppelboomRichard C E Anderson
Mar 25, 2014·Therapeutic Hypothermia and Temperature Management·Anna SandestigPer-Olof Grände
Jan 22, 2011·Developmental Neuroscience·Patrick M KochanekHülya Bayır
Feb 14, 2016·Brain Research·Tamil Selvan AnthonymuthuHülya Bayır
May 22, 2010·Expert Opinion on Investigational Drugs·Donald G Stein, David W Wright
Jun 18, 2015·The American Journal of the Medical Sciences·John B HiebertJanet D Pierce
Mar 19, 2013·Pediatric Neurology·Jainn-Jim LinKuang-Lin Lin
Jul 8, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Rachel P BergerMichael J Bell
Apr 15, 2011·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Thomas J L'EcuyerRichard S Van der Heide
Oct 5, 2010·Seminars in Pediatric Surgery·Stephen E Morrow, Matthew Pearson
Mar 1, 2016·Brain Research·Anthony E Kline, Corina O Bondi
Dec 16, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yasutaka OdaJohn T Povlishock
Jul 8, 2015·Neurochemical Research·Mary C McKennaCourtney L Robertson
Apr 7, 2012·Mediators of Inflammation·Michael FrinkFrank Hildebrand
Jun 12, 2013·Redox Report : Communications in Free Radical Research·Karelle LéonErwan L'Her
Feb 15, 2011·Journal of Biomedicine & Biotechnology·Jinn-Rung KuoChung-Ching Chio
Feb 1, 2012·Brain Research Bulletin·Enci Mary KanJia Lu
Oct 5, 2011·Nutrition·Robert A McPherson, Gil Hardy
Jun 5, 2015·Current Treatment Options in Pediatrics·Robert NewmyerEricka L Fink
Oct 26, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Mathilde ChevinGuillaume Sébire
Dec 16, 2016·International Journal of Molecular Sciences·Mingyi ZhaoXiao-Kang Li
Mar 30, 2018·International Journal of Molecular Sciences·Norma AlvaTeresa Carbonell
Aug 28, 2010·Critical Care Medicine·Shelly D Timmons
Jan 18, 2018·Italian Journal of Pediatrics·Liviana Da DaltUNKNOWN Italian Society of Pediatrics (SIP)
Jul 22, 2009·Current Opinion in Anaesthesiology·Pimwan Sookplung, Monica S Vavilala
Dec 15, 2010·The Journal of Trauma·Jinn-Rung KuoChung-Ching Chio

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