Therapeutic iloprost for the treatment of acute respiratory distress syndrome (ARDS) (the ThIlo trial): a prospective, randomized, multicenter phase II study

Trials
Helene HaeberlePeter Rosenberger

Abstract

Acute respiratory distress syndrome (ARDS) is caused by rapid-onset (within hours) acute inflammatory processes in lung tissue, and it is a life-threatening condition with high mortality. The treatment of ARDS to date is focused on the prevention of further iatrogenic damage of the lung rather than the treatment of the initial inflammatory process. Several preclinical studies have revealed a beneficial effect of iloprost on the control of pulmonary inflammation, and in a small number of patients with ARDS, iloprost treatment resulted in improved oxygenation. Therefore, we plan to conduct a large multicenter trial to evaluate the effect of iloprost on ARDS. The Therapeutic Iloprost during ARDS trial (ThIlo trial) is a multicenter, randomized, single blinded, clinical phase II trial assessing the efficacy of inhaled iloprost for the prevention of the development and progression of ARDS in critically ill patients. One hundred fifty critically ill patients suffering from acute ARDS will be treated either by nebulized iloprost or NaCl 0.9% for 5 days. Blood samples will be drawn at defined time points to elucidate the serum levels of iloprost and inflammatory markers during treatment. Mechanical ventilation will be standardized. In ...Continue Reading

Associated Clinical Trials

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Citations

Feb 9, 2021·Respiratory Medicine Case Reports·Alida FilippiniTony Sabatini
Aug 10, 2021·Frontiers in Physiology·Sabina SahanicIvan Tancevski
Sep 17, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Mareike GierhardtNatascha Sommer

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Methods Mentioned

BETA
pregnancy test

Clinical Trials Mentioned

NCT03111212

Software Mentioned

ThIlo

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