Therapeutic Immunization against Glioblastoma

International Journal of Molecular Sciences
Virgil E J C SchijnsApostolos Stathopoulos

Abstract

Glioblastoma is the most common form of brain cancer in adults that produces severe damage to the brain leading to a very poor survival prognosis. The standard of care for glioblastoma is usually surgery, as well as radiotherapy followed by systemic temozolomide chemotherapy, resulting in a median survival time of about 12 to 15 months. Despite these therapeutic efforts, the tumor returns in the vast majority of patients. When relapsing, statistics suggest an imminent death dependent on the size of the tumor, the Karnofsky Performance Status, and the tumor localization. Following the standard of care, the administration of Bevacizumab, inhibiting the growth of the tumor vasculature, is an approved medicinal treatment option approved in the United States, but not in the European Union, as well as the recently approved alternating electric fields (AEFs) generator NovoTTF/Optune. However, it is clear that regardless of the current treatment regimens, glioma patients continue to have dismal prognosis and novel treatments are urgently needed. Here, we describe different approaches of recently developed therapeutic glioma brain cancer vaccines, which stimulate the patient's immune system to recognize tumor-associated antigens (TAA) o...Continue Reading

References

Dec 1, 1995·Seminars in Cancer Biology·J J Lewis, A N Houghton
Aug 1, 1997·Nature Medicine·G AmbrosiniD C Altieri
Jun 1, 2001·Nature Medicine·J W Fabre
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jul 5, 2008·The American Journal of Pathology·Jenilyn J VirreyFlorence M Hofman
Mar 31, 2009·Cancer Immunology, Immunotherapy : CII·Alban GervaisJacky Bernard
Mar 17, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick Y WenSusan M Chang
Jul 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John K ParkPeter McL Black
Oct 12, 2011·Journal of Neuro-oncology·David A ReardonHenry S Friedman
Aug 1, 2012·Cancer Immunology, Immunotherapy : CII·Surasak PhuphanichJohn S Yu
Nov 9, 2012·Neuro-oncology·Michael WellerWolfgang Wick
Jul 2, 2015·Neuro-oncology·Kathryn M FieldMark A Rosenthal
Aug 25, 2015·Current Oncology·O Gallego
Dec 15, 2015·Therapeutics and Clinical Risk Management·Yoshitaka Narita
Dec 17, 2015·JAMA : the Journal of the American Medical Association·Roger StuppZvi Ram
Jan 8, 2016·Current Neurology and Neuroscience Reports·Kenneth D SwansonEric T Wong
Jan 27, 2016·Clinical Neurology and Neurosurgery·Nicola MontemurroRiccardo Vannozzi
Oct 21, 2016·Cancer Immunology, Immunotherapy : CII·Robert A FenstermakerAlan D Hutson
May 21, 2017·Journal of Neuro-oncology·Roberto Jose DiazRicardo J Komotar

❮ Previous
Next ❯

Citations

Jul 1, 2020·Immunological Reviews·Virgil SchijnsEd C Lavelle
May 18, 2019·Cellular and Molecular Neurobiology·Changlin HuangGuanghui Li
Nov 5, 2019·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Wenbing ShangguanNan Tian
Dec 20, 2018·International Journal of Molecular Sciences·Thomas C ChenAxel H Schönthal
Apr 25, 2019·Cancers·Sascha MarxBernhard H Rauch
Apr 24, 2021·Journal of Biomedical Science·Nan SunJinquan Cai
Feb 3, 2022·Current Neurology and Neuroscience Reports·Michael ZhangMichael Lim

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
PCR
imaging techniques

Clinical Trials Mentioned

NCT02455557
NCT03072134
NCT00045968
NCT01280552
NCT02546102
NCT01903330

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved