Therapeutic index of H1-antihistamines: example of cetirizine

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
J P Rihoux

Abstract

The second generation H1 antihistamines were considered to have an improved risk/benefit ratio because of their low penetration into the brain and their very low incidence of CNS depressant effects. Nevertheless, the cardiac rhythm disturbances described under terfenadine and astemizole intake drew the attention to the fact that the low penetration into the brain is only one limited item in the evaluation of their respective therapeutic indices. A correct evaluation of the therapeutic index should always comprise a large series of items: all desired and not desired effects and properties should be considered together with the physicobiochemical mechanisms of the drugs at cell and membrane levels.

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Citations

May 7, 2002·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·K Y Tam, L Quéré
Feb 20, 2019·Environmental Toxicology and Chemistry·Lisa BittnerNils Klüver
Apr 3, 2016·Biomedical Chromatography : BMC·Maria KatselouSotiris Athanaselis

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