Therapeutic inhibition of leukocyte recruitment in inflammatory diseases

Current Opinion in Pharmacology
Zoltán Szekanecz, A E Koch

Abstract

The ingress of leukocytes into sites of inflammation is crucial for the pathogenesis of arthritis and other inflammatory conditions. Chemokines, their receptors and cellular adhesion molecules (CAMs) are involved in this process. Here, the roles of the most relevant chemokines, chemokine receptors and CAMs are briefly reviewed. There have been several attempts to target chemokine- and CAM-mediated pathways in preclinical studies using animal models of arthritis, and in a limited number of human studies. In this review, the most recent advances in anti-chemokine and anti-adhesion therapeutic strategies are summarized.

Citations

Jun 1, 2005·Pharmacology & Therapeutics·María Jesús SanzEsteban J Morcillo
Jun 4, 2013·Vascular Cell·Nicola MaruottiDomenico Ribatti
Sep 30, 2006·Arthritis Research & Therapy·Else N KopPaul P Tak
Oct 25, 2008·Arthritis Research & Therapy·Zoltán Szekanecz, Alisa E Koch
Feb 20, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Pilar LondonoDanny Zipris
Mar 31, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Travis R WolterDanny Zipris
Aug 12, 2006·Burns : Journal of the International Society for Burn Injuries·Daizhi PengShiliang Wang
Nov 19, 2004·Journal of Leukocyte Biology·Karyn Yonekawa, John M Harlan
Jan 20, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Min HeMadhav Bhatia
Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karkada Mohan, Thomas B Issekutz
Sep 29, 2006·Journal of Medicinal Chemistry·Holger K UlbrichGerd Dannhardt

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