PMID: 8081644Jun 1, 1994Paper

Therapeutic interaction of lamotrigine and sodium valproate in intractable myoclonic epilepsy

Seizure : the Journal of the British Epilepsy Association
C D Ferrie, C P Panayiotopoulos


The clinical and EEG features of a 13-year-old girl with an unusual refractory myoclonic epilepsy is presented. Control was achieved only when lamotrigine was combined with sodium valproate. This may represent a specific pharmacodynamic interaction between these drugs with implications for therapy in the generalized epilepsies.


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