Therapeutic lymph node dissection in melanoma: different prognosis for different macrometastasis sites?

Annals of Surgical Oncology
K P WeversH J Hoekstra

Abstract

The prognostic significance of primary tumor location, especially the poor prognosis for melanomas in the scalp and neck region, is well established. However, the prognosis for different sites of nodal macrometastasis has never been studied. This study investigated the prognostic value of the location of macrometastasis in terms of recurrence and survival rates after therapeutic lymph node dissection (TLND). All consecutive FDG-PET-staged melanoma patients with palpable and cytologically proven lymph node metastases operated at our clinic between 2003 and 2011 were included. Disease-free survival and disease-specific survival (DSS) were compared for nodal metastases in the groin, axilla, and neck regions by multivariable analysis. A total of 149 patients underwent TLND; there were 70 groin (47 %), 57 axillary (38 %), and 22 neck (15 %) dissections. During a median follow-up of 18 (range 1-98) months, 102 patients (68 %) developed recurrent disease. Distant recurrence was the first sign of progressive disease in 78, 76, and 55 % of the groin, axilla, and neck groups, respectively (p = 0.26). Low involved/total lymph nodes (L/N) ratio (p < 0.001) and absence of extranodal growth pattern (p = 0.05) were independent predictors of a...Continue Reading

References

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Aug 5, 2011·Journal of Surgical Oncology·Adam C BergerMichael J Mastrangelo

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Citations

Feb 9, 2013·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Oliver J SmithGary L Ross
Oct 16, 2014·Annals of Surgical Oncology·Pasquali SandroRossi Carlo Riccardo
Aug 9, 2016·Annals of Surgical Oncology·Mark A HealySandra L Wong
Feb 13, 2018·Melanoma Research·Alessandro A TestoriUNKNOWN European Organization for Research and Treatment of Cancer (EORTC) Melanoma Group

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Methods Mentioned

BETA
dissection
biopsy
dissections

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