Therapeutic mild hypothermia: effects on coagulopathy and survival in a rat hemorrhagic shock model

The Journal of Trauma
Shinichiro IwamotoToshihisa Sakamoto

Abstract

: To determine the effects of therapeutic hypothermia on coagulation parameters during hemorrhagic shock (HS) and fluid resuscitation and on survival, in a rat HS model. : Under light anesthesia and spontaneous breathing, 24 rats underwent HS (phase I) for 90 minutes, during which 2.5 mL/100 g blood was withdrawn over 15 minutes; fluid resuscitation (phase II) for 60 minutes, during which no blood was reinfused but 5.0 mL/100 g lactated Ringer's solution was infused over 30 minutes; and an observation (phase III) without anesthesia until 72 hour. After the volume-controlled hemorrhage, rats were randomized into a hypothermia group (n = 12, 33 degrees C) or a normothermia group (n = 12, 38 degrees C). The rectal temperature in each group was maintained during phases I and II. Whole blood coagulopathy was assessed by Sonoclot analysis (SA) at baseline and the end of phases I and II. Fibrinolysis parameters of thrombin-antithrombin III complex and plasma-alpha-2-plasmin inhibitor complex were also monitored. : At 72 hour, 10 of 12 hypothermia group rats, and 5 of 12 normothermia group rats remained alive (p < 0.05). Fluid resuscitation significantly decreased hematocrit (20% +/- 5%) compared with baseline (33% +/- 5%; p < 0.05) in...Continue Reading

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Citations

Jan 21, 2011·Orvosi hetilap·Eniko KovácsEndre Zima
Dec 27, 2011·Thrombosis Research·Daniel FrithKarim Brohi
Dec 18, 2012·Emergency Medicine Journal : EMJ·Samuel Edwin Moffatt
Jan 8, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Kaiyuan LiTanshi Li
Mar 21, 2013·The Journal of Trauma and Acute Care Surgery·Juliane MohrPhilipp Mommsen
Jul 11, 2012·Shock·Uroghupatei P IyeghaGreg J Beilman
Mar 19, 2015·Shock·Natasha van ZylJohn F Fraser
Dec 21, 2011·The Journal of Trauma·Ying WangHong Zhou
Dec 21, 2019·World Journal of Emergency Surgery : WJES·Cedric GangloffKarine Pichavant-Rafini

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