Therapeutic modalities and novel approaches in regenerative medicine for COVID-19.

International Journal of Antimicrobial Agents
Roya RamezankhaniCatherine Verfaillie

Abstract

The recent coronavirus disease 2019 outbreak around the world has had an enormous impact on the global health burden, threatening the lives of many individuals, and has had severe socio-economic consequences. Many pharmaceutical and biotechnology companies have commenced intensive research on different therapeutic strategies, from repurposed antiviral drugs to vaccines and monoclonal antibodies to prevent the spread of the disease and treat infected patients. Among the various strategies, advanced therapeutic approaches including cell- and gene-editing-based therapeutics are also being investigated, and initial results in in-vitro and early phase I studies have been promising. However, further assessments are required. This article reviews the underlying mechanisms for the pathogenesis of severe acute respiratory syndrome coronavirus-2, and discusses available therapeutic candidates and advanced modalities that are being evaluated in in-vitro/in-vivo models and are of note in clinical trials.

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Jan 5, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Nikoo Hossein-KhannazerMassoud Vosough
Jan 31, 2021·Stem Cell Research & Therapy·Seyed-Mohammad Reza HashemianHossein Baharvand
May 14, 2021·Stem Cell Research & Therapy·Birbal SinghMohammad Ali Moni

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Clinical Trials Mentioned

NCT04310592
NCT04283461
NCT04313127
NCT04336410
NCT04276896
NCT04299724
NCT04333368
NCT04392778
NCT04366063
NCT04349631

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